Quantified electroencephalogram in adult patients with Down's syndrome

Tiziana Locatelli; Carla Fornara; Stefania Medaglini; Margherita Alberoni; Massimo Franceschi; Laura Rinaldi; Mauro Comola; Letizia Leocani; Nicola Canal; Giancarlo Comi

Quantified electroencephalogram in adult patients with Down's syndrome

Tiziana Locatelli, Carla Fornara, Stefania Medaglini, Margherita Alberoni, Massimo Franceschi, Laura Rinaldi, Mauro Comola, Letizia Leocani, Nicola Canal, Giancarlo Comi

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of this study was the assessment of quantified EEG (qEEG) changes in adult patients with Down's syndrome (DS) with different degrees of mental retardation. Forty-five patients, 33 aged 20-35 years (young DS patients, Y-DS), and 12 aged 35-56 years (old DS patients, O-DS), underwent qEEG and a battery of neuropsychological tests. In comparison with age-matched controls, qEEG was abnormal in 35 (77%) DS patients, 24 Y-DS (72.7%) and 11 O-DS (91.6%). The prevalence of EEG abnormalities increased with the severity of mental retardation: qEEG was abnormal in 72% of 22 mildly, in 75% of 8 moderately, in 90% of 11 severely mentally retarded and 100% of 4 demented O-DS. Band powers, and particularly theta power, differentiate the DS group well from controls, whereas the alpha peak is a better descriptor of aging and cognitive decline.

Original language	English
Pages (from-to)	215-223
Number of pages	9
Journal	Developmental Brain Dysfunction
Volume	9
Issue number	4
Publication status	Published - 1996

Keywords

Aging
Dementia
Down's syndrome
Electroencephalography
Mapping

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

Cite this

@article{72adb1146cb74b90b4e70224795304c6,

title = "Quantified electroencephalogram in adult patients with Down's syndrome",

abstract = "The aim of this study was the assessment of quantified EEG (qEEG) changes in adult patients with Down's syndrome (DS) with different degrees of mental retardation. Forty-five patients, 33 aged 20-35 years (young DS patients, Y-DS), and 12 aged 35-56 years (old DS patients, O-DS), underwent qEEG and a battery of neuropsychological tests. In comparison with age-matched controls, qEEG was abnormal in 35 (77%) DS patients, 24 Y-DS (72.7%) and 11 O-DS (91.6%). The prevalence of EEG abnormalities increased with the severity of mental retardation: qEEG was abnormal in 72% of 22 mildly, in 75% of 8 moderately, in 90% of 11 severely mentally retarded and 100% of 4 demented O-DS. Band powers, and particularly theta power, differentiate the DS group well from controls, whereas the alpha peak is a better descriptor of aging and cognitive decline.",

keywords = "Aging, Dementia, Down's syndrome, Electroencephalography, Mapping",

author = "Tiziana Locatelli and Carla Fornara and Stefania Medaglini and Margherita Alberoni and Massimo Franceschi and Laura Rinaldi and Mauro Comola and Letizia Leocani and Nicola Canal and Giancarlo Comi",

year = "1996",

language = "English",

volume = "9",

pages = "215--223",

journal = "Developmental Brain Dysfunction",

issn = "1019-5815",

publisher = "S. Karger AG",

number = "4",

}

TY - JOUR

T1 - Quantified electroencephalogram in adult patients with Down's syndrome

AU - Locatelli, Tiziana

AU - Fornara, Carla

AU - Medaglini, Stefania

AU - Alberoni, Margherita

AU - Franceschi, Massimo

AU - Rinaldi, Laura

AU - Comola, Mauro

AU - Leocani, Letizia

AU - Canal, Nicola

AU - Comi, Giancarlo

PY - 1996

Y1 - 1996

N2 - The aim of this study was the assessment of quantified EEG (qEEG) changes in adult patients with Down's syndrome (DS) with different degrees of mental retardation. Forty-five patients, 33 aged 20-35 years (young DS patients, Y-DS), and 12 aged 35-56 years (old DS patients, O-DS), underwent qEEG and a battery of neuropsychological tests. In comparison with age-matched controls, qEEG was abnormal in 35 (77%) DS patients, 24 Y-DS (72.7%) and 11 O-DS (91.6%). The prevalence of EEG abnormalities increased with the severity of mental retardation: qEEG was abnormal in 72% of 22 mildly, in 75% of 8 moderately, in 90% of 11 severely mentally retarded and 100% of 4 demented O-DS. Band powers, and particularly theta power, differentiate the DS group well from controls, whereas the alpha peak is a better descriptor of aging and cognitive decline.

AB - The aim of this study was the assessment of quantified EEG (qEEG) changes in adult patients with Down's syndrome (DS) with different degrees of mental retardation. Forty-five patients, 33 aged 20-35 years (young DS patients, Y-DS), and 12 aged 35-56 years (old DS patients, O-DS), underwent qEEG and a battery of neuropsychological tests. In comparison with age-matched controls, qEEG was abnormal in 35 (77%) DS patients, 24 Y-DS (72.7%) and 11 O-DS (91.6%). The prevalence of EEG abnormalities increased with the severity of mental retardation: qEEG was abnormal in 72% of 22 mildly, in 75% of 8 moderately, in 90% of 11 severely mentally retarded and 100% of 4 demented O-DS. Band powers, and particularly theta power, differentiate the DS group well from controls, whereas the alpha peak is a better descriptor of aging and cognitive decline.

KW - Aging

KW - Dementia

KW - Down's syndrome

KW - Electroencephalography

KW - Mapping

UR - http://www.scopus.com/inward/record.url?scp=9444284908&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=9444284908&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:9444284908

SN - 1019-5815

VL - 9

SP - 215

EP - 223

JO - Developmental Brain Dysfunction

JF - Developmental Brain Dysfunction

IS - 4

ER -

Quantified electroencephalogram in adult patients with Down's syndrome

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this