Quantified electroencephalogram in adult patients with Down's syndrome

Tiziana Locatelli, Carla Fornara, Stefania Medaglini, Margherita Alberoni, Massimo Franceschi, Laura Rinaldi, Mauro Comola, Letizia Leocani, Nicola Canal, Giancarlo Comi

Research output: Contribution to journalArticlepeer-review


The aim of this study was the assessment of quantified EEG (qEEG) changes in adult patients with Down's syndrome (DS) with different degrees of mental retardation. Forty-five patients, 33 aged 20-35 years (young DS patients, Y-DS), and 12 aged 35-56 years (old DS patients, O-DS), underwent qEEG and a battery of neuropsychological tests. In comparison with age-matched controls, qEEG was abnormal in 35 (77%) DS patients, 24 Y-DS (72.7%) and 11 O-DS (91.6%). The prevalence of EEG abnormalities increased with the severity of mental retardation: qEEG was abnormal in 72% of 22 mildly, in 75% of 8 moderately, in 90% of 11 severely mentally retarded and 100% of 4 demented O-DS. Band powers, and particularly theta power, differentiate the DS group well from controls, whereas the alpha peak is a better descriptor of aging and cognitive decline.

Original languageEnglish
Pages (from-to)215-223
Number of pages9
JournalDevelopmental Brain Dysfunction
Issue number4
Publication statusPublished - 1996


  • Aging
  • Dementia
  • Down's syndrome
  • Electroencephalography
  • Mapping

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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