Quality of life in women diagnosed with breast cancer after a 12-month treatment of lifestyle modifications

C. Montagnese; G. Porciello; S. Vitale; E. Palumbo; A. Crispo; M. Grimaldi; I. Calabrese; R. Pica; M. Prete; L. Falzone; M. Libra; S. Cubisino; L. Poletto; V. Martinuzzo; S. Coluccia; N. Esindi; F. Nocerino; A. Minopoli; B. Grilli; P.C. Fiorillo; M. Cuomo; E. Cavalcanti; G. Thomas; D. Cianniello; M. Pinto; M. De Laurentiis; C. Pacilio; M. Rinaldo; M. D’aiuto; D. Serraino; S. Massarut; L. Caggiari; C. Evangelista; A. Steffan; F. Catalano; G.L. Banna; G. Scandurra; F. Ferraù; R. Rossello; G. Antonelli; G. Guerra; A. Farina; F. Messina; G. Riccardi; D. Gatti; D.J.A. Jenkins; E. Celentano; G. Botti; L.S.A. Augustin

doi:10.3390/nu13010136

Quality of life in women diagnosed with breast cancer after a 12-month treatment of lifestyle modifications

C. Montagnese, G. Porciello, S. Vitale, E. Palumbo, A. Crispo, M. Grimaldi, I. Calabrese, R. Pica, M. Prete, L. Falzone, M. Libra, S. Cubisino, L. Poletto, V. Martinuzzo, S. Coluccia, N. Esindi, F. Nocerino, A. Minopoli, B. Grilli, P.C. FiorilloM. Cuomo, E. Cavalcanti, G. Thomas, D. Cianniello, M. Pinto, M. De Laurentiis, C. Pacilio, M. Rinaldo, M. D’aiuto, D. Serraino, S. Massarut, L. Caggiari, C. Evangelista, A. Steffan, F. Catalano, G.L. Banna, G. Scandurra, F. Ferraù, R. Rossello, G. Antonelli, G. Guerra, A. Farina, F. Messina, G. Riccardi, D. Gatti, D.J.A. Jenkins, E. Celentano, G. Botti, L.S.A. Augustin

Research output: Contribution to journal › Article › peer-review

Abstract

Healthy lifestyles are associated with better health-related quality of life (HRQoL), favorable prognosis and lower mortality in breast cancer (BC) survivors. We investigated changes in HRQoL after a 12-month lifestyle modification program in 227 BC survivors participating in DEDiCa trial (Mediterranean diet, exercise, vitamin D). HRQoL was evaluated through validated questionnaires: EQ-5D-3L, EORTC-QLQ-C30 and EORTC QLQ-BR23. Baseline changes were tested using analysis of variance. Multiple regression analyses were performed to assess treatment effects on HRQoL. Increases were observed in global health status (p < 0.001), physical (p = 0.003), role (p = 0.002) and social functioning (p < 0.001), body image (p < 0.001), future perspective (p < 0.001), well-being (p = 0.001), and reductions in fatigue (p < 0.001), nausea and vomiting (p = 0.015), dyspnea (p = 0.001), consti-pation (p = 0.049), financial problems (p = 0.012), sexual functioning (p = 0.025), systematic therapy side effects (p < 0.001) and breast symptoms (p = 0.004). Multiple regression analyses found inverse associations between changes in BMI and global health status (p = 0.048) and between serum 25(OH)D levels and breast symptoms (p = 0.002). A healthy lifestyle treatment of traditional Mediterranean diet and exercise may impact positively on HRQoL in BC survivors possibly through reductions in body weight while vitamin D sufficiency may improve BC-related symptoms. These findings are relevant to BC survivors whose lower HRQoL negatively affects treatment compliance and disease outcomes. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Original language	English
Pages (from-to)	1-15
Number of pages	15
Journal	Nutrients
Volume	13
Issue number	1
DOIs	https://doi.org/10.3390/nu13010136
Publication status	Published - 2021

Keywords

Breast cancer
Lifestyle
Mediterranean diet
Physical activity
Quality of life
Vitamin D
25 hydroxyvitamin D
vitamin D
adult
Article
body image
body mass
breast cancer
cancer survivor
constipation
controlled study
dyspnea
European Organization for Research and Treatment of Cancer Quality of Life Questionnaire BR23
European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30
European Quality of Life 5 Dimensions 3 Level questionnaire
fatigue
female
financial deficit
global health
health status
human
human tissue
lifestyle modification
major clinical study
middle aged
multicenter study
multiple regression
nausea and vomiting
physical capacity
quality of life
quality of life assessment
randomized controlled trial
sexuality
social interaction
wellbeing
breast tumor
clinical trial
complication
diet
dietary supplement
healthy lifestyle
kinesiotherapy
patient compliance
psychology
questionnaire
survivorship
treatment outcome
Adult
Breast Neoplasms
Cancer Survivors
Diet Surveys
Diet, Mediterranean
Dietary Supplements
Exercise Therapy
Female
Health Status
Healthy Lifestyle
Humans
Middle Aged
Patient Compliance
Quality of Life
Surveys and Questionnaires
Survivorship
Treatment Outcome

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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099252827&doi=10.3390%2fnu13010136&partnerID=40&md5=4b15afbb2333b594e0a6a88ea3c5d5ee

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Montagnese, C., Porciello, G., Vitale, S., Palumbo, E., Crispo, A., Grimaldi, M., Calabrese, I., Pica, R., Prete, M., Falzone, L., Libra, M., Cubisino, S., Poletto, L., Martinuzzo, V., Coluccia, S., Esindi, N., Nocerino, F., Minopoli, A., Grilli, B., ... Augustin, L. S. A. (2021). Quality of life in women diagnosed with breast cancer after a 12-month treatment of lifestyle modifications. Nutrients, 13(1), 1-15. https://doi.org/10.3390/nu13010136

Montagnese, C, Porciello, G, Vitale, S, Palumbo, E, Crispo, A , Grimaldi, M, Calabrese, I, Pica, R, Prete, M, Falzone, L, Libra, M, Cubisino, S, Poletto, L, Martinuzzo, V, Coluccia, S, Esindi, N, Nocerino, F, Minopoli, A, Grilli, B, Fiorillo, PC, Cuomo, M , Cavalcanti, E, Thomas, G, Cianniello, D, Pinto, M, De Laurentiis, M , Pacilio, C , Rinaldo, M, D’aiuto, M, Serraino, D , Massarut, S , Caggiari, L , Evangelista, C , Steffan, A, Catalano, F, Banna, GL, Scandurra, G, Ferraù, F, Rossello, R, Antonelli, G, Guerra, G, Farina, A, Messina, F, Riccardi, G, Gatti, D, Jenkins, DJA, Celentano, E, Botti, G & Augustin, LSA 2021, 'Quality of life in women diagnosed with breast cancer after a 12-month treatment of lifestyle modifications', Nutrients, vol. 13, no. 1, pp. 1-15. https://doi.org/10.3390/nu13010136

@article{72399bf5837b4f489a803c65b1180f60,

title = "Quality of life in women diagnosed with breast cancer after a 12-month treatment of lifestyle modifications",

abstract = "Healthy lifestyles are associated with better health-related quality of life (HRQoL), favorable prognosis and lower mortality in breast cancer (BC) survivors. We investigated changes in HRQoL after a 12-month lifestyle modification program in 227 BC survivors participating in DEDiCa trial (Mediterranean diet, exercise, vitamin D). HRQoL was evaluated through validated questionnaires: EQ-5D-3L, EORTC-QLQ-C30 and EORTC QLQ-BR23. Baseline changes were tested using analysis of variance. Multiple regression analyses were performed to assess treatment effects on HRQoL. Increases were observed in global health status (p < 0.001), physical (p = 0.003), role (p = 0.002) and social functioning (p < 0.001), body image (p < 0.001), future perspective (p < 0.001), well-being (p = 0.001), and reductions in fatigue (p < 0.001), nausea and vomiting (p = 0.015), dyspnea (p = 0.001), consti-pation (p = 0.049), financial problems (p = 0.012), sexual functioning (p = 0.025), systematic therapy side effects (p < 0.001) and breast symptoms (p = 0.004). Multiple regression analyses found inverse associations between changes in BMI and global health status (p = 0.048) and between serum 25(OH)D levels and breast symptoms (p = 0.002). A healthy lifestyle treatment of traditional Mediterranean diet and exercise may impact positively on HRQoL in BC survivors possibly through reductions in body weight while vitamin D sufficiency may improve BC-related symptoms. These findings are relevant to BC survivors whose lower HRQoL negatively affects treatment compliance and disease outcomes. {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

keywords = "Breast cancer, Lifestyle, Mediterranean diet, Physical activity, Quality of life, Vitamin D, 25 hydroxyvitamin D, vitamin D, adult, Article, body image, body mass, breast cancer, cancer survivor, constipation, controlled study, dyspnea, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire BR23, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30, European Quality of Life 5 Dimensions 3 Level questionnaire, fatigue, female, financial deficit, global health, health status, human, human tissue, lifestyle modification, major clinical study, middle aged, multicenter study, multiple regression, nausea and vomiting, physical capacity, quality of life, quality of life assessment, randomized controlled trial, sexuality, social interaction, wellbeing, breast tumor, clinical trial, complication, diet, dietary supplement, healthy lifestyle, kinesiotherapy, patient compliance, psychology, questionnaire, survivorship, treatment outcome, Adult, Breast Neoplasms, Cancer Survivors, Diet Surveys, Diet, Mediterranean, Dietary Supplements, Exercise Therapy, Female, Health Status, Healthy Lifestyle, Humans, Middle Aged, Patient Compliance, Quality of Life, Surveys and Questionnaires, Survivorship, Treatment Outcome",

author = "C. Montagnese and G. Porciello and S. Vitale and E. Palumbo and A. Crispo and M. Grimaldi and I. Calabrese and R. Pica and M. Prete and L. Falzone and M. Libra and S. Cubisino and L. Poletto and V. Martinuzzo and S. Coluccia and N. Esindi and F. Nocerino and A. Minopoli and B. Grilli and P.C. Fiorillo and M. Cuomo and E. Cavalcanti and G. Thomas and D. Cianniello and M. Pinto and {De Laurentiis}, M. and C. Pacilio and M. Rinaldo and M. D{\textquoteright}aiuto and D. Serraino and S. Massarut and L. Caggiari and C. Evangelista and A. Steffan and F. Catalano and G.L. Banna and G. Scandurra and F. Ferra{\`u} and R. Rossello and G. Antonelli and G. Guerra and A. Farina and F. Messina and G. Riccardi and D. Gatti and D.J.A. Jenkins and E. Celentano and G. Botti and L.S.A. Augustin",

note = "Cited By :8 Export Date: 4 February 2022 Correspondence Address: Porciello, G.; Epidemiology and Biostatistics Unit, Italy; email: g.porciello@istitutotumori.na.it",

year = "2021",

doi = "10.3390/nu13010136",

language = "English",

volume = "13",

pages = "1--15",

journal = "Nutrients",

issn = "2072-6643",

publisher = "MDPI AG",

number = "1",

}

TY - JOUR

T1 - Quality of life in women diagnosed with breast cancer after a 12-month treatment of lifestyle modifications

AU - Montagnese, C.

AU - Porciello, G.

AU - Vitale, S.

AU - Palumbo, E.

AU - Crispo, A.

AU - Grimaldi, M.

AU - Calabrese, I.

AU - Pica, R.

AU - Prete, M.

AU - Falzone, L.

AU - Libra, M.

AU - Cubisino, S.

AU - Poletto, L.

AU - Martinuzzo, V.

AU - Coluccia, S.

AU - Esindi, N.

AU - Nocerino, F.

AU - Minopoli, A.

AU - Grilli, B.

AU - Fiorillo, P.C.

AU - Cuomo, M.

AU - Cavalcanti, E.

AU - Thomas, G.

AU - Cianniello, D.

AU - Pinto, M.

AU - De Laurentiis, M.

AU - Pacilio, C.

AU - Rinaldo, M.

AU - D’aiuto, M.

AU - Serraino, D.

AU - Massarut, S.

AU - Caggiari, L.

AU - Evangelista, C.

AU - Steffan, A.

AU - Catalano, F.

AU - Banna, G.L.

AU - Scandurra, G.

AU - Ferraù, F.

AU - Rossello, R.

AU - Antonelli, G.

AU - Guerra, G.

AU - Farina, A.

AU - Messina, F.

AU - Riccardi, G.

AU - Gatti, D.

AU - Jenkins, D.J.A.

AU - Celentano, E.

AU - Botti, G.

AU - Augustin, L.S.A.

N1 - Cited By :8 Export Date: 4 February 2022 Correspondence Address: Porciello, G.; Epidemiology and Biostatistics Unit, Italy; email: g.porciello@istitutotumori.na.it

PY - 2021

Y1 - 2021

N2 - Healthy lifestyles are associated with better health-related quality of life (HRQoL), favorable prognosis and lower mortality in breast cancer (BC) survivors. We investigated changes in HRQoL after a 12-month lifestyle modification program in 227 BC survivors participating in DEDiCa trial (Mediterranean diet, exercise, vitamin D). HRQoL was evaluated through validated questionnaires: EQ-5D-3L, EORTC-QLQ-C30 and EORTC QLQ-BR23. Baseline changes were tested using analysis of variance. Multiple regression analyses were performed to assess treatment effects on HRQoL. Increases were observed in global health status (p < 0.001), physical (p = 0.003), role (p = 0.002) and social functioning (p < 0.001), body image (p < 0.001), future perspective (p < 0.001), well-being (p = 0.001), and reductions in fatigue (p < 0.001), nausea and vomiting (p = 0.015), dyspnea (p = 0.001), consti-pation (p = 0.049), financial problems (p = 0.012), sexual functioning (p = 0.025), systematic therapy side effects (p < 0.001) and breast symptoms (p = 0.004). Multiple regression analyses found inverse associations between changes in BMI and global health status (p = 0.048) and between serum 25(OH)D levels and breast symptoms (p = 0.002). A healthy lifestyle treatment of traditional Mediterranean diet and exercise may impact positively on HRQoL in BC survivors possibly through reductions in body weight while vitamin D sufficiency may improve BC-related symptoms. These findings are relevant to BC survivors whose lower HRQoL negatively affects treatment compliance and disease outcomes. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

AB - Healthy lifestyles are associated with better health-related quality of life (HRQoL), favorable prognosis and lower mortality in breast cancer (BC) survivors. We investigated changes in HRQoL after a 12-month lifestyle modification program in 227 BC survivors participating in DEDiCa trial (Mediterranean diet, exercise, vitamin D). HRQoL was evaluated through validated questionnaires: EQ-5D-3L, EORTC-QLQ-C30 and EORTC QLQ-BR23. Baseline changes were tested using analysis of variance. Multiple regression analyses were performed to assess treatment effects on HRQoL. Increases were observed in global health status (p < 0.001), physical (p = 0.003), role (p = 0.002) and social functioning (p < 0.001), body image (p < 0.001), future perspective (p < 0.001), well-being (p = 0.001), and reductions in fatigue (p < 0.001), nausea and vomiting (p = 0.015), dyspnea (p = 0.001), consti-pation (p = 0.049), financial problems (p = 0.012), sexual functioning (p = 0.025), systematic therapy side effects (p < 0.001) and breast symptoms (p = 0.004). Multiple regression analyses found inverse associations between changes in BMI and global health status (p = 0.048) and between serum 25(OH)D levels and breast symptoms (p = 0.002). A healthy lifestyle treatment of traditional Mediterranean diet and exercise may impact positively on HRQoL in BC survivors possibly through reductions in body weight while vitamin D sufficiency may improve BC-related symptoms. These findings are relevant to BC survivors whose lower HRQoL negatively affects treatment compliance and disease outcomes. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

KW - Breast cancer

KW - Lifestyle

KW - Mediterranean diet

KW - Physical activity

KW - Quality of life

KW - Vitamin D

KW - 25 hydroxyvitamin D

KW - vitamin D

KW - adult

KW - Article

KW - body image

KW - body mass

KW - breast cancer

KW - cancer survivor

KW - constipation

KW - controlled study

KW - dyspnea

KW - European Organization for Research and Treatment of Cancer Quality of Life Questionnaire BR23

KW - European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30

KW - European Quality of Life 5 Dimensions 3 Level questionnaire

KW - fatigue

KW - female

KW - financial deficit

KW - global health

KW - health status

KW - human

KW - human tissue

KW - lifestyle modification

KW - major clinical study

KW - middle aged

KW - multicenter study

KW - multiple regression

KW - nausea and vomiting

KW - physical capacity

KW - quality of life

KW - quality of life assessment

KW - randomized controlled trial

KW - sexuality

KW - social interaction

KW - wellbeing

KW - breast tumor

KW - clinical trial

KW - complication

KW - diet

KW - dietary supplement

KW - healthy lifestyle

KW - kinesiotherapy

KW - patient compliance

KW - psychology

KW - questionnaire

KW - survivorship

KW - treatment outcome

KW - Adult

KW - Breast Neoplasms

KW - Cancer Survivors

KW - Diet Surveys

KW - Diet, Mediterranean

KW - Dietary Supplements

KW - Exercise Therapy

KW - Female

KW - Health Status

KW - Healthy Lifestyle

KW - Humans

KW - Middle Aged

KW - Patient Compliance

KW - Quality of Life

KW - Surveys and Questionnaires

KW - Survivorship

KW - Treatment Outcome

U2 - 10.3390/nu13010136

DO - 10.3390/nu13010136

M3 - Article

SN - 2072-6643

VL - 13

SP - 1

EP - 15

JO - Nutrients

JF - Nutrients

IS - 1

ER -

Quality of life in women diagnosed with breast cancer after a 12-month treatment of lifestyle modifications

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Keywords

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