Quality of Life in Patients With Hypoparathyroidism After Treatment for Thyroid Cancer

Matthias Büttner, Laura D. Locati, Monica Pinto, Cláudia Araújo, Iwona M. Tomaszewska, Naomi Kiyota, E. Vidhubala, Christine Brannan, Eva Hammerlid, Olga Husson, Dina Salem, Georgios Ioannidis, Eva Gamper, Juan Ignacio Arraras, Guy Andry, Johanna Inhestern, Juliane Theurer, Katherine Taylor, Susanne Singer

Research output: Contribution to journalArticlepeer-review


PURPOSE: Surgical complications such as hypoparathyroidism (HPT) or vocal cord palsy are seldom assessed when the quality of life (QOL) in thyroid cancer patients is investigated. The aim of this study was to measure the QOL difference in thyroid cancer survivors with and without HPT. METHODS: Participants for this analysis were enrolled in 13 countries from a study that pilot-tested a thyroid cancer-specific QOL instrument. They were included if they had been diagnosed with thyroid cancer at least 9 months previously. QOL was measured using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core (EORTC QLQ-C30) and some items on HPT symptoms (eg, tingling in fingers or toes). HPT status and other clinical data were extracted from the patients' medical charts. Comparisons of QOL domains between patients with and without HPT were performed using Mann-Whitney U test. The occurrence of HPT-related symptoms was compared using chi-square tests. Multiple ordinal regression analysis was performed to evaluate factors that might affect QOL. RESULTS: Eighty-nine patients participated in this study, 17 of whom were considered to have HPT. Patients in the HPT group reported significantly reduced QOL in 9 of the 15 scales of the EORTC QLQ-C30 compared to patients without HPT. Regression analysis showed that HPT was independently negatively associated with various scales of the QLQ-C30. Both groups showed a high prevalence of typical HPT symptoms. CONCLUSION: Thyroid cancer patients with HPT report significantly impaired QOL compared to thyroid cancer survivors without HPT. The assessment of HPT should be considered when measuring QOL in thyroid cancer patients.

Original languageEnglish
JournalThe Journal of clinical endocrinology and metabolism
Issue number12
Publication statusPublished - Dec 1 2020


  • hypoparathyroidism
  • quality of life
  • thyroid cancer
  • well-being

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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