TY - JOUR
T1 - Quality of life in elderly patients with essential thrombocythaemia. An Italian multicentre study
AU - Oliva, Esther Natalie
AU - Piccin, Andrea
AU - Mazzucconi, Maria Gabriella
AU - Morra, Enrica
AU - Recine, Umberto
AU - Pogliani, Enrico Maria
AU - Pane, Fabrizio
AU - Gobbi, Marco
AU - Gugliotta, Luigi
AU - Krampera, Mauro
AU - Cascavilla, Nicola
AU - Cacciola, Rossella
AU - Cacciola, Emma
AU - Fioritoni, Giuseppe
AU - Fanin, Renato
AU - Liberati, Anna Marina
AU - Angelucci, Emanuele
AU - Tura, Sante
PY - 2012/4
Y1 - 2012/4
N2 - Essential thrombocythaemia (ET) is a myeloproliferative neoplasm characterized by elevated platelet counts and increased incidence of thrombosis and haemorrhage. Median age at diagnosis is 65-70 years. Life expectancy is similar to that of the healthy population. Symptoms and complications may affect quality of life (QoL); in particular, in elderly patients ET may represent an additional burden. We performed a survey in 494 elderly ET patients to evaluate patient-reported outcomes (PROs). Comorbidities were present in 305 (62%) patients. Factorial analysis based on survey items representing psychological aspects of daily life identified an "attitude domain" with four clusters of patients: (A) very pessimistic (n=99), (B) pessimistic (n=101), (C) optimistic (n=90), and (D) very optimistic (n=107). Patients in cluster A had more comorbidities (p=0.003) while patients in cluster D required fewer medical visits and were less disturbed by medications (p
AB - Essential thrombocythaemia (ET) is a myeloproliferative neoplasm characterized by elevated platelet counts and increased incidence of thrombosis and haemorrhage. Median age at diagnosis is 65-70 years. Life expectancy is similar to that of the healthy population. Symptoms and complications may affect quality of life (QoL); in particular, in elderly patients ET may represent an additional burden. We performed a survey in 494 elderly ET patients to evaluate patient-reported outcomes (PROs). Comorbidities were present in 305 (62%) patients. Factorial analysis based on survey items representing psychological aspects of daily life identified an "attitude domain" with four clusters of patients: (A) very pessimistic (n=99), (B) pessimistic (n=101), (C) optimistic (n=90), and (D) very optimistic (n=107). Patients in cluster A had more comorbidities (p=0.003) while patients in cluster D required fewer medical visits and were less disturbed by medications (p
KW - Elderly
KW - Essential thrombocythaemia
KW - Myeloproliferative disorders
KW - Psychosocial Oncology
KW - Quality of life
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U2 - 10.1007/s00277-011-1341-x
DO - 10.1007/s00277-011-1341-x
M3 - Article
C2 - 21964878
AN - SCOPUS:84860803261
SN - 0939-5555
VL - 91
SP - 527
EP - 532
JO - Revue d'hématologie
JF - Revue d'hématologie
IS - 4
ER -