Quality of life in elderly patients with essential thrombocythaemia. An Italian multicentre study

Esther Natalie Oliva, Andrea Piccin, Maria Gabriella Mazzucconi, Enrica Morra, Umberto Recine, Enrico Maria Pogliani, Fabrizio Pane, Marco Gobbi, Luigi Gugliotta, Mauro Krampera, Nicola Cascavilla, Rossella Cacciola, Emma Cacciola, Giuseppe Fioritoni, Renato Fanin, Anna Marina Liberati, Emanuele Angelucci, Sante Tura

Research output: Contribution to journalArticlepeer-review


Essential thrombocythaemia (ET) is a myeloproliferative neoplasm characterized by elevated platelet counts and increased incidence of thrombosis and haemorrhage. Median age at diagnosis is 65-70 years. Life expectancy is similar to that of the healthy population. Symptoms and complications may affect quality of life (QoL); in particular, in elderly patients ET may represent an additional burden. We performed a survey in 494 elderly ET patients to evaluate patient-reported outcomes (PROs). Comorbidities were present in 305 (62%) patients. Factorial analysis based on survey items representing psychological aspects of daily life identified an "attitude domain" with four clusters of patients: (A) very pessimistic (n=99), (B) pessimistic (n=101), (C) optimistic (n=90), and (D) very optimistic (n=107). Patients in cluster A had more comorbidities (p=0.003) while patients in cluster D required fewer medical visits and were less disturbed by medications (p

Original languageEnglish
Pages (from-to)527-532
Number of pages6
JournalAnnals of Hematology
Issue number4
Publication statusPublished - Apr 2012


  • Elderly
  • Essential thrombocythaemia
  • Myeloproliferative disorders
  • Psychosocial Oncology
  • Quality of life

ASJC Scopus subject areas

  • Hematology


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