TY - JOUR
T1 - QTc interval prolongation in HIV-infected patients
T2 - A case-control study by 24-hour Holter ECG recording
AU - Fiorentini, Alessandra
AU - Petrosillo, Nicola
AU - Di Stefano, Angelo
AU - Cicalini, Stefania
AU - Borgognoni, Laura
AU - Boumis, Evangelo
AU - Tubani, Luigi
AU - Chinello, Pierangelo
PY - 2012/12/23
Y1 - 2012/12/23
N2 - Background: Aim of the study was to assess QTc interval by a 24-hour ECG recording in a group of HIV-infected individuals with a basal prolonged QTc. The risk factors associated with QTc prolongation and the indices of cardiovascular autonomic control were also evaluated.Methods: A case-control study was performed using as cases 32 HIV-infected patients with prolonged (>440 msec) QTc interval as assessed by Holter ECG, and as controls 64 HIV-infected subjects with normal QTc interval. Autonomic function was evaluated by heart rate variability analysis during 24-hour recording. Results: Duration of HIV disease was significantly longer among cases than among controls (p=0.04). Waist/hip ratio was also higher among cases than among controls (p=0.05). Frequency domain analysis showed the absence of physiologic decrease of low frequency (LF) in the night period in both cases and controls. The LF night in cases showed a statistically significant reduction when compared with controls (p=0.007). Conclusions: In our study group, QTc interval prolongation was associated with a longer duration of HIV infection and with a greater waist/hip ratio. HIV patients with QTc interval prolongation and with a longer duration of HIV infection were more likely to have an impairment of parasympathetic and sympathetic cardiac component.
AB - Background: Aim of the study was to assess QTc interval by a 24-hour ECG recording in a group of HIV-infected individuals with a basal prolonged QTc. The risk factors associated with QTc prolongation and the indices of cardiovascular autonomic control were also evaluated.Methods: A case-control study was performed using as cases 32 HIV-infected patients with prolonged (>440 msec) QTc interval as assessed by Holter ECG, and as controls 64 HIV-infected subjects with normal QTc interval. Autonomic function was evaluated by heart rate variability analysis during 24-hour recording. Results: Duration of HIV disease was significantly longer among cases than among controls (p=0.04). Waist/hip ratio was also higher among cases than among controls (p=0.05). Frequency domain analysis showed the absence of physiologic decrease of low frequency (LF) in the night period in both cases and controls. The LF night in cases showed a statistically significant reduction when compared with controls (p=0.007). Conclusions: In our study group, QTc interval prolongation was associated with a longer duration of HIV infection and with a greater waist/hip ratio. HIV patients with QTc interval prolongation and with a longer duration of HIV infection were more likely to have an impairment of parasympathetic and sympathetic cardiac component.
KW - Cardiac autonomic function
KW - HIV
KW - Holter ECG
KW - QTc interval
UR - http://www.scopus.com/inward/record.url?scp=84872228065&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872228065&partnerID=8YFLogxK
U2 - 10.1186/1471-2261-12-124
DO - 10.1186/1471-2261-12-124
M3 - Article
C2 - 23259665
AN - SCOPUS:84872228065
SN - 1471-2261
VL - 12
JO - BMC Cardiovascular Disorders
JF - BMC Cardiovascular Disorders
M1 - 124
ER -