TY - JOUR
T1 - QOLEC2: a randomized controlled trial on nutritional and respiratory counseling after esophagectomy for cancer
AU - Pinto, Eleonora
AU - Nardi, Maria Teresa
AU - Marchi, Rita
AU - Cavallin, Francesco
AU - Alfieri, Rita
AU - Saadeh, Luca
AU - Cagol, Matteo
AU - Baldan, Ilaria
AU - Saraceni, Elisabetta
AU - Parotto, Matteo
AU - Baratto, Fabio
AU - Caberlotto, Cristina
AU - Vianello, Andrea
AU - Castoro, Carlo
AU - Scarpa, Marco
N1 - Funding Information:
This study was supported by a grant from the Berlucchi Foundation (Brescia, Italy) to C.C. The funding source had no involvement in the study design, data collection and analysis, or writing of this article.
Publisher Copyright:
© 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/2
Y1 - 2021/2
N2 - Background: Esophagectomy for cancer strongly impairs quality of life. The aim of this trial was to evaluate the effect of the nutritional and respiratory counseling on postoperative quality of life. Methods: At hospital discharge, patients were randomized into four groups receiving respectively: nutritional and respiratory counseling, nutritional counseling alone, respiratory counseling alone, or standard care. The main endpoint was the impairment in quality of life in the first month after surgery. Linear mixed effect models were estimated to assess mean score differences (MDs) in quality of life scores. Results: Patients receiving nutritional counseling reported less appetite loss (MD − 17.7, 95% CI − 32.2 to −3.3) than those not receiving nutritional counseling at 1 month after surgery. Dyspnea was similar between patients receiving vs. those not receiving respiratory counseling (MD − 3.1, 95% CI − 10.8 to 4.6). Global quality of life was clinically similar between patients receiving vs. those not receiving nutritional counseling over time (MD 0.9, 95% CI − 5.5 to 7.3), as well as in patients receiving vs. those not receiving respiratory counseling over time (MD 0.7, 95% CI − 5.9 to 7.2). Conclusions: Intensive postoperative care does not affect global quality of life even if nutritional counseling reduced appetite loss.
AB - Background: Esophagectomy for cancer strongly impairs quality of life. The aim of this trial was to evaluate the effect of the nutritional and respiratory counseling on postoperative quality of life. Methods: At hospital discharge, patients were randomized into four groups receiving respectively: nutritional and respiratory counseling, nutritional counseling alone, respiratory counseling alone, or standard care. The main endpoint was the impairment in quality of life in the first month after surgery. Linear mixed effect models were estimated to assess mean score differences (MDs) in quality of life scores. Results: Patients receiving nutritional counseling reported less appetite loss (MD − 17.7, 95% CI − 32.2 to −3.3) than those not receiving nutritional counseling at 1 month after surgery. Dyspnea was similar between patients receiving vs. those not receiving respiratory counseling (MD − 3.1, 95% CI − 10.8 to 4.6). Global quality of life was clinically similar between patients receiving vs. those not receiving nutritional counseling over time (MD 0.9, 95% CI − 5.5 to 7.3), as well as in patients receiving vs. those not receiving respiratory counseling over time (MD 0.7, 95% CI − 5.9 to 7.2). Conclusions: Intensive postoperative care does not affect global quality of life even if nutritional counseling reduced appetite loss.
KW - Esophageal cancer
KW - Esophagectomy
KW - Nutritional counseling
KW - Quality of life
KW - Randomized controlled trial
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U2 - 10.1007/s00520-020-05573-z
DO - 10.1007/s00520-020-05573-z
M3 - Article
C2 - 32572611
AN - SCOPUS:85086778246
SN - 0941-4355
VL - 29
SP - 1025
EP - 1033
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
IS - 2
ER -