A series of pyrrolo[3,2-c]quinoline derivatives were synthesised and evaluated as inhibitors of selected enzymes of the kynurenine pathway. 7-Chloro-3-methyl-1H-pyrrolo[3,2-c]quinoline-4-carboxylic acid (7a) was found to be a relatively potent and selective inhibitor of kynurenine-3-hydroxylase (KYN3-OHase). A molecular modelling study showed a good superimposition of 7a with PNU-156561 and kynurenine the natural substrate of KYN-3-OHase.
|Number of pages||9|
|Journal||Farmaco, Edizione Pratica|
|Publication status||Published - Mar 31 1999|
- Enzyme inhibition
ASJC Scopus subject areas
- Drug Discovery
- Pharmaceutical Science