Purely cutaneous Rosai-Dorfman disease

G. Annessi, A. Giannetti

Research output: Contribution to journalArticlepeer-review


Cutaneous lesions of Rosai-Dorfman disease (RDD) are usually associated with nodal or other extranodal localization. We describe a female patient with RDD clinically limited to the skin. The patient presented with asymptomatic red-brown papules and nodules on the legs, arms, back, and nose. Histologically, the lesions consisted of a proliferation of large histiocytes occasionally showing emperipolesis. Histiocytes were also observed within dilated lymphatic vessels. Immunohistochemical study showed that histiocytes expressed S-100 protein and both macrophage and monocyte markers. All lesions reserved completely with Roentgen therapy. No recurrence has been observed over a 3-year follow-up period.

Original languageEnglish
Pages (from-to)749-753
Number of pages5
JournalBritish Journal of Dermatology
Issue number4
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Dermatology


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