Proximal tubular renal dysfunction on treatment with valproic acid

Alberto Bettinelli; Claudio Zucca; Lucia Radice; Sara Stucchi; Alberto Tettamanti; Mario G. Bianchetti

Proximal tubular renal dysfunction on treatment with valproic acid

Alberto Bettinelli, Claudio Zucca, Lucia Radice, Sara Stucchi, Alberto Tettamanti, Mario G. Bianchetti

Istituto "Eugenio Medea" - Associazione La Nostra Famiglia

Research output: Contribution to journal › Article › peer-review

Abstract

A 10-year-old severely disabled Italian boy on long-term treatment with valproic acid presented with tubular proteinuria, generalized aminoaciduria, normoglycemic glucosuria, and phosphate wasting. Since no other explanation for these renal tubular abnormalities was found, the treatment with valproic acid was discontinued. The abnormalities resolved within 5 months after discontinuing this anticonvulsant. We recommend screening patients on long-term anticonvulsant therapy with valproate periodically for renal tubular dysfunction, either via urinalysis or via measurement of urinary lactate/creatinine ratio, if clinical suspicion is high.

Original language	English
Pages (from-to)	189-190
Number of pages	2
Journal	Journal of Pediatric Neurology
Volume	6
Issue number	2
Publication status	Published - 2008

Keywords

Epilepsy
Fanconi syndrome
Kidney disease
Valproic acid

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Clinical Neurology

Cite this

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title = "Proximal tubular renal dysfunction on treatment with valproic acid",

abstract = "A 10-year-old severely disabled Italian boy on long-term treatment with valproic acid presented with tubular proteinuria, generalized aminoaciduria, normoglycemic glucosuria, and phosphate wasting. Since no other explanation for these renal tubular abnormalities was found, the treatment with valproic acid was discontinued. The abnormalities resolved within 5 months after discontinuing this anticonvulsant. We recommend screening patients on long-term anticonvulsant therapy with valproate periodically for renal tubular dysfunction, either via urinalysis or via measurement of urinary lactate/creatinine ratio, if clinical suspicion is high.",

keywords = "Epilepsy, Fanconi syndrome, Kidney disease, Valproic acid",

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AU - Radice, Lucia

AU - Stucchi, Sara

AU - Tettamanti, Alberto

AU - Bianchetti, Mario G.

PY - 2008

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N2 - A 10-year-old severely disabled Italian boy on long-term treatment with valproic acid presented with tubular proteinuria, generalized aminoaciduria, normoglycemic glucosuria, and phosphate wasting. Since no other explanation for these renal tubular abnormalities was found, the treatment with valproic acid was discontinued. The abnormalities resolved within 5 months after discontinuing this anticonvulsant. We recommend screening patients on long-term anticonvulsant therapy with valproate periodically for renal tubular dysfunction, either via urinalysis or via measurement of urinary lactate/creatinine ratio, if clinical suspicion is high.

AB - A 10-year-old severely disabled Italian boy on long-term treatment with valproic acid presented with tubular proteinuria, generalized aminoaciduria, normoglycemic glucosuria, and phosphate wasting. Since no other explanation for these renal tubular abnormalities was found, the treatment with valproic acid was discontinued. The abnormalities resolved within 5 months after discontinuing this anticonvulsant. We recommend screening patients on long-term anticonvulsant therapy with valproate periodically for renal tubular dysfunction, either via urinalysis or via measurement of urinary lactate/creatinine ratio, if clinical suspicion is high.

KW - Epilepsy

KW - Fanconi syndrome

KW - Kidney disease

KW - Valproic acid

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Proximal tubular renal dysfunction on treatment with valproic acid

Abstract

Keywords

ASJC Scopus subject areas

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