Proteomics imaging and the kidney

Fulvio Magni; Maciej Lalowski; Veronica Mainini; Martina Marchetti-Deschmann; Clizia Chinello; Andrea Urbani; Marc Baumann

doi:10.5301/jn.5000243

Proteomics imaging and the kidney

Fulvio Magni, Maciej Lalowski, Veronica Mainini, Martina Marchetti-Deschmann, Clizia Chinello, Andrea Urbani, Marc Baumann

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Matrix-assisted laser desorption/ionization (MALDI) and mass spectrometry (MS) imaging are advanced technologies capable of revealing the spatial distribution of different molecules - e.g., drugs and their metabolites, endogenous lipids and complex peptides/ proteins - directly in tissue specimens at the same time. Information obtained regarding tissues by MALDI profiling/imaging analysis can be correlated with other MS-based techniques, auxiliary imaging technologies and routine immunohistochemical stainings. In this review we describe the MALDI profiling/imaging technologies, providing examples of their application in kidney research.

Original language	English
Pages (from-to)	430-436
Number of pages	7
Journal	Journal of Nephrology
Volume	26
Issue number	3
DOIs	https://doi.org/10.5301/jn.5000243
Publication status	Published - May 2013

Keywords

Imaging mass spectrometry
Kidney
Tissue profiling

ASJC Scopus subject areas

Nephrology

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10.5301/jn.5000243

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abstract = "Matrix-assisted laser desorption/ionization (MALDI) and mass spectrometry (MS) imaging are advanced technologies capable of revealing the spatial distribution of different molecules - e.g., drugs and their metabolites, endogenous lipids and complex peptides/ proteins - directly in tissue specimens at the same time. Information obtained regarding tissues by MALDI profiling/imaging analysis can be correlated with other MS-based techniques, auxiliary imaging technologies and routine immunohistochemical stainings. In this review we describe the MALDI profiling/imaging technologies, providing examples of their application in kidney research.",

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AU - Magni, Fulvio

AU - Lalowski, Maciej

AU - Mainini, Veronica

AU - Marchetti-Deschmann, Martina

AU - Chinello, Clizia

AU - Urbani, Andrea

AU - Baumann, Marc

PY - 2013/5

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AB - Matrix-assisted laser desorption/ionization (MALDI) and mass spectrometry (MS) imaging are advanced technologies capable of revealing the spatial distribution of different molecules - e.g., drugs and their metabolites, endogenous lipids and complex peptides/ proteins - directly in tissue specimens at the same time. Information obtained regarding tissues by MALDI profiling/imaging analysis can be correlated with other MS-based techniques, auxiliary imaging technologies and routine immunohistochemical stainings. In this review we describe the MALDI profiling/imaging technologies, providing examples of their application in kidney research.

KW - Imaging mass spectrometry

KW - Kidney

KW - Tissue profiling

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Proteomics imaging and the kidney

Abstract

Keywords

ASJC Scopus subject areas

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