Proteomic evaluation of milk from different mammalian species as a substitute for breast milk

Enza D'Auria, Carlo Agostoni, Marcello Giovannini, Enrica Riva, Rolf Zetterström, Riccardo Fortin, Gian Franco Greppi, Luigi Bonizzi, Paola Roncada

Research output: Contribution to journalArticlepeer-review


As milk represents the main source of nutrition for infants, the question of an effective human milk substitute becomes mandatory when a formula-fed baby is allergic to cows' milk proteins. In this case, formulas containing extensively hydrolysed milk proteins should be preferred, but even such a formula may cause allergic reactions in highly sensitive patients. If there is evidence of cows' milk allergy with IgE-associated symptoms, after 6 mo of age, a soy bean formula may be recommended only when tolerance to soy protein has been established by clinical challenge. In infants with allergic reactions to cows' milk proteins, even after extensive hydrolysation, proteomic techniques coupled to immunological methods may make it possible to select other milk products that do not contain the same allergens as ordinary cow's milk. In this paper, evidence will be presented that proteomic evaluation of proteins from different mammalian species may be a suitable method of testing whether proteins from the milk of different mammalian species may be used as a substitute for untreated bovine milk. Conclusion: Proteomic evaluation of milk from different mammalian species may not only be of help when recommending suitable feeding in cases of cows' milk allergy but also gives new insight into the background to allergic reactions caused by milk proteins.

Original languageEnglish
Pages (from-to)1708-1713
Number of pages6
JournalActa Paediatrica, International Journal of Paediatrics
Issue number12
Publication statusPublished - Feb 1 2005


  • Cows' milk allergy
  • Infant feeding
  • Proteomic technique

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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