Prospective, randomized study of atrioventricular ablation and mode-switching, dual chamber pacemaker implantation versus medical therapy in drug-resistant paroxysmal atrial fibrillation: The PAF study

M. Brignole; L. Gianfranchi; C. Menozzi; P. Alboni; G. Musso; M. G. Bongiorni; M. Gasparini; A. Raviele; G. Lolli; N. Paparella; S. Acquarone

doi:10.1053/eupc.1998.0007

Prospective, randomized study of atrioventricular ablation and mode-switching, dual chamber pacemaker implantation versus medical therapy in drug-resistant paroxysmal atrial fibrillation: The PAF study

M. Brignole, L. Gianfranchi, C. Menozzi, P. Alboni, G. Musso, M. G. Bongiorni, M. Gasparini, A. Raviele, G. Lolli, N. Paparella, S. Acquarone

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

We performed a prospective randomized 6-month evaluation of the clinical effects of atrioventricular junctional ablation together with placement of a DDDR mode-switching pacemaker vs pharmacological treatment in 43 patients with intolerable paroxysmal atrial fibrillation not controlled with antiarrhythmic drugs. Ablation and pacemaker treatment were highly effective and superior to drug therapy in controlling symptoms and improving quality of life. However, discontinuation of drug therapy exposed patients to further recurrences of paroxysmal atrial fibrillation and the risk of developing permanent atrial fibrillation.

Original language	English
Pages (from-to)	15-19
Number of pages	5
Journal	Europace
Volume	1
Issue number	1
DOIs	https://doi.org/10.1053/eupc.1998.0007
Publication status	Published - 1999

Keywords

Atrial fibrillation
Catheter ablation pacemaker
Mode-switching

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1053/eupc.1998.0007

Cite this

Brignole, M., Gianfranchi, L., Menozzi, C., Alboni, P., Musso, G., Bongiorni, M. G., Gasparini, M., Raviele, A., Lolli, G., Paparella, N., & Acquarone, S. (1999). Prospective, randomized study of atrioventricular ablation and mode-switching, dual chamber pacemaker implantation versus medical therapy in drug-resistant paroxysmal atrial fibrillation: The PAF study. Europace, 1(1), 15-19. https://doi.org/10.1053/eupc.1998.0007

Brignole, M, Gianfranchi, L, Menozzi, C, Alboni, P, Musso, G, Bongiorni, MG, Gasparini, M, Raviele, A, Lolli, G, Paparella, N & Acquarone, S 1999, 'Prospective, randomized study of atrioventricular ablation and mode-switching, dual chamber pacemaker implantation versus medical therapy in drug-resistant paroxysmal atrial fibrillation: The PAF study', Europace, vol. 1, no. 1, pp. 15-19. https://doi.org/10.1053/eupc.1998.0007

@article{efdcdebed1464faea45089605d4d44be,

title = "Prospective, randomized study of atrioventricular ablation and mode-switching, dual chamber pacemaker implantation versus medical therapy in drug-resistant paroxysmal atrial fibrillation: The PAF study",

abstract = "We performed a prospective randomized 6-month evaluation of the clinical effects of atrioventricular junctional ablation together with placement of a DDDR mode-switching pacemaker vs pharmacological treatment in 43 patients with intolerable paroxysmal atrial fibrillation not controlled with antiarrhythmic drugs. Ablation and pacemaker treatment were highly effective and superior to drug therapy in controlling symptoms and improving quality of life. However, discontinuation of drug therapy exposed patients to further recurrences of paroxysmal atrial fibrillation and the risk of developing permanent atrial fibrillation.",

keywords = "Atrial fibrillation, Catheter ablation pacemaker, Mode-switching",

author = "M. Brignole and L. Gianfranchi and C. Menozzi and P. Alboni and G. Musso and Bongiorni, {M. G.} and M. Gasparini and A. Raviele and G. Lolli and N. Paparella and S. Acquarone",

year = "1999",

doi = "10.1053/eupc.1998.0007",

language = "English",

volume = "1",

pages = "15--19",

journal = "Europace",

issn = "1099-5129",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - Prospective, randomized study of atrioventricular ablation and mode-switching, dual chamber pacemaker implantation versus medical therapy in drug-resistant paroxysmal atrial fibrillation

T2 - The PAF study

AU - Brignole, M.

AU - Gianfranchi, L.

AU - Menozzi, C.

AU - Alboni, P.

AU - Musso, G.

AU - Bongiorni, M. G.

AU - Gasparini, M.

AU - Raviele, A.

AU - Lolli, G.

AU - Paparella, N.

AU - Acquarone, S.

PY - 1999

Y1 - 1999

N2 - We performed a prospective randomized 6-month evaluation of the clinical effects of atrioventricular junctional ablation together with placement of a DDDR mode-switching pacemaker vs pharmacological treatment in 43 patients with intolerable paroxysmal atrial fibrillation not controlled with antiarrhythmic drugs. Ablation and pacemaker treatment were highly effective and superior to drug therapy in controlling symptoms and improving quality of life. However, discontinuation of drug therapy exposed patients to further recurrences of paroxysmal atrial fibrillation and the risk of developing permanent atrial fibrillation.

AB - We performed a prospective randomized 6-month evaluation of the clinical effects of atrioventricular junctional ablation together with placement of a DDDR mode-switching pacemaker vs pharmacological treatment in 43 patients with intolerable paroxysmal atrial fibrillation not controlled with antiarrhythmic drugs. Ablation and pacemaker treatment were highly effective and superior to drug therapy in controlling symptoms and improving quality of life. However, discontinuation of drug therapy exposed patients to further recurrences of paroxysmal atrial fibrillation and the risk of developing permanent atrial fibrillation.

KW - Atrial fibrillation

KW - Catheter ablation pacemaker

KW - Mode-switching

UR - http://www.scopus.com/inward/record.url?scp=10644252875&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10644252875&partnerID=8YFLogxK

U2 - 10.1053/eupc.1998.0007

DO - 10.1053/eupc.1998.0007

M3 - Article

C2 - 11220531

AN - SCOPUS:10644252875

SN - 1099-5129

VL - 1

SP - 15

EP - 19

JO - Europace

JF - Europace

IS - 1

ER -

Prospective, randomized study of atrioventricular ablation and mode-switching, dual chamber pacemaker implantation versus medical therapy in drug-resistant paroxysmal atrial fibrillation: The PAF study

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this