Proposal of a modified scintigraphic method to evaluate duodenogastroesophageal reflux

N. Borsato, L. Bonavina, P. Zanco, B. Saitta, F. Chierichetti, A. Peracchia, G. Ferlin

Research output: Contribution to journalArticlepeer-review


Hepatobiliary scintigraphy with 99mTc-HIDA offers a noninvasive method to detect duodenogastric reflux. Biliary reflux was graded using the persistence rather than the intensity of the radioactive refluxate: Grade 0 was considered the absence of reflux, minimal reflux, or reflux in the first 10-15 min; Grade 1 was repetitive reflux lasting less than 10 min; Grade 2 was persistent reflux; and Grade 3 was reflux up to the esophagus. Twenty-five patients with foregut symptoms were studied and results were compared to 24-hr gastric pH monitoring. Scintigraphy and pH monitoring agreed in 15 out of 25 patients (60%), but no correlation was found with the endoscopic findings. The rationale for this approach is based on pathophysiologic evidence that damage to gastric and/or esophageal mucosa is mainly related to the prolonged contact time with duodenal contents. This technique seems to allow a complete functional evaluation of the esophagogastroduodenal tract without causing adjunctive irradiation or discomfort to the patient.

Original languageEnglish
Pages (from-to)436-440
Number of pages5
JournalJournal of Nuclear Medicine
Issue number3
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology


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