Proposal for a new subtype of the zoonotic genotype 3 Hepatitis E virus: HEV-3l

Luca De Sabato; Philippe Lemey; Bram Vrancken; Lebana Bonfanti; Letizia Ceglie; Gabriele Vaccari; Ilaria Di Bartolo

doi:10.1016/j.virusres.2018.02.010

Proposal for a new subtype of the zoonotic genotype 3 Hepatitis E virus: HEV-3l

Luca De Sabato, Philippe Lemey, Bram Vrancken, Lebana Bonfanti, Letizia Ceglie, Gabriele Vaccari, Ilaria Di Bartolo

Istituto Superiore di Sanita'

Research output: Contribution to journal › Article › peer-review

Abstract

The near-complete genomic sequences of two hepatitis E virus (HEV) strains, detected from feces of infected pigs, were obtained. Phylogenetic analysis and p-distance comparisons of the complete coding regions showed a close relationship to the French swine strain FR-SHEV3c-like detected in 2006 (p-distance value 0.101), belonging to HEV-3 but not assigned to any known subtype. The three HEV sequences showed, relatively high nucleotide distances (p-distance >0.129) compared to the other defined HEV subtype references and unclassified strains. The HEV classification criteria and the high sequence similarity suggest that these strains can be assigned to a putative novel subtype of genotype 3, HEV-3l.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Virus Research
Volume	248
DOIs	https://doi.org/10.1016/j.virusres.2018.02.010
Publication status	Published - Mar 15 2018

Keywords

Complete genome
Genotype 3
Hepatitis E virus
Next generation sequencing
Subtype
Swine

ASJC Scopus subject areas

Virology
Infectious Diseases
Cancer Research

Access to Document

10.1016/j.virusres.2018.02.010

Cite this

@article{89a0583d1fca4d8db45c8646ca15f0c7,

title = "Proposal for a new subtype of the zoonotic genotype 3 Hepatitis E virus: HEV-3l",

abstract = "The near-complete genomic sequences of two hepatitis E virus (HEV) strains, detected from feces of infected pigs, were obtained. Phylogenetic analysis and p-distance comparisons of the complete coding regions showed a close relationship to the French swine strain FR-SHEV3c-like detected in 2006 (p-distance value 0.101), belonging to HEV-3 but not assigned to any known subtype. The three HEV sequences showed, relatively high nucleotide distances (p-distance >0.129) compared to the other defined HEV subtype references and unclassified strains. The HEV classification criteria and the high sequence similarity suggest that these strains can be assigned to a putative novel subtype of genotype 3, HEV-3l.",

keywords = "Complete genome, Genotype 3, Hepatitis E virus, Next generation sequencing, Subtype, Swine",

author = "{De Sabato}, Luca and Philippe Lemey and Bram Vrancken and Lebana Bonfanti and Letizia Ceglie and Gabriele Vaccari and {Di Bartolo}, Ilaria",

year = "2018",

month = mar,

day = "15",

doi = "10.1016/j.virusres.2018.02.010",

language = "English",

volume = "248",

pages = "1--4",

journal = "Virus Research",

issn = "0168-1702",

publisher = "Elsevier",

}

TY - JOUR

T1 - Proposal for a new subtype of the zoonotic genotype 3 Hepatitis E virus

T2 - HEV-3l

AU - De Sabato, Luca

AU - Lemey, Philippe

AU - Vrancken, Bram

AU - Bonfanti, Lebana

AU - Ceglie, Letizia

AU - Vaccari, Gabriele

AU - Di Bartolo, Ilaria

PY - 2018/3/15

Y1 - 2018/3/15

N2 - The near-complete genomic sequences of two hepatitis E virus (HEV) strains, detected from feces of infected pigs, were obtained. Phylogenetic analysis and p-distance comparisons of the complete coding regions showed a close relationship to the French swine strain FR-SHEV3c-like detected in 2006 (p-distance value 0.101), belonging to HEV-3 but not assigned to any known subtype. The three HEV sequences showed, relatively high nucleotide distances (p-distance >0.129) compared to the other defined HEV subtype references and unclassified strains. The HEV classification criteria and the high sequence similarity suggest that these strains can be assigned to a putative novel subtype of genotype 3, HEV-3l.

AB - The near-complete genomic sequences of two hepatitis E virus (HEV) strains, detected from feces of infected pigs, were obtained. Phylogenetic analysis and p-distance comparisons of the complete coding regions showed a close relationship to the French swine strain FR-SHEV3c-like detected in 2006 (p-distance value 0.101), belonging to HEV-3 but not assigned to any known subtype. The three HEV sequences showed, relatively high nucleotide distances (p-distance >0.129) compared to the other defined HEV subtype references and unclassified strains. The HEV classification criteria and the high sequence similarity suggest that these strains can be assigned to a putative novel subtype of genotype 3, HEV-3l.

KW - Complete genome

KW - Genotype 3

KW - Hepatitis E virus

KW - Next generation sequencing

KW - Subtype

KW - Swine

UR - http://www.scopus.com/inward/record.url?scp=85042210107&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042210107&partnerID=8YFLogxK

U2 - 10.1016/j.virusres.2018.02.010

DO - 10.1016/j.virusres.2018.02.010

M3 - Article

C2 - 29452164

AN - SCOPUS:85042210107

SN - 0168-1702

VL - 248

SP - 1

EP - 4

JO - Virus Research

JF - Virus Research

ER -

Proposal for a new subtype of the zoonotic genotype 3 Hepatitis E virus: HEV-3l

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this