Prone 3D abus vs hhus: Diagnostic accuracy and potentialities

G. Gatta, G. Di Grezia, D. Donatello, G. Falco, S. Bertozzi, A. P. Londero, M. Giordano, S. Magliocchetti, R. Grassi, G. Pace

Research output: Contribution to journalArticlepeer-review


Purpose: Aim of the study is to evaluate the accuracy of SOFIA: automated 3D prone breast US vs hand held manual ultrasonography in breast cancer prevention. Material and Methods: 57 female patients have been involved in this prospective study; the first in Italy and one of the first across Europe. All patients underwent clinical exam, hand held ultrasonography, 3D automated breast ultrasonography in prone position, mammography if >40 yo, in selected cases breast MRI. Results: Compared to mammography, the association with 3D automated breast ultrasonography in prone position improved the diagnostic accuracy (respectively 8%, CI 2.22-19.23% vs 98.25%, CI 90.61-99.84%). 41 benign lesions and 15 cancers have been detected; one case of breast cancer has been missed because of the position (axillary region) on SOFIA. Conclusion: 3D automated breast ultrasonography in prone position might be helpful to improve cancer detection in dense breasts, even if a little tendency towards the size underestimation of benign lesions has been demonstrated.

Original languageEnglish
Pages (from-to)23-38
Number of pages16
Issue numberSpecial Issue
Publication statusPublished - Apr 2020


  • Automated breast ultrasound
  • Breast cancer screening
  • Dense breasts

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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