TY - JOUR
T1 - Prolongation by warfarin of 'template' bleeding time in rats
T2 - A vitamin K-dependent effect
AU - Reyers, I.
AU - De Gaetano, G.
AU - Donati, M. B.
PY - 1986
Y1 - 1986
N2 - Administration of warfarin to rats induced not only the well-known anticoagulant effect, but also an impairment of primary hemostasis as reflected by a significant prolongation of the 'template' bleeding time. This effect was very closely associated with lowering of the prothrombin complex level and was reversed by administration of vitamin K. It is suggested that some of the clotting factors known to be vitamin K-dependent also play a role in primary hemostasis; alternatively, a putative vascular 'bleeding factor' could be modulated by vitamin K availability.
AB - Administration of warfarin to rats induced not only the well-known anticoagulant effect, but also an impairment of primary hemostasis as reflected by a significant prolongation of the 'template' bleeding time. This effect was very closely associated with lowering of the prothrombin complex level and was reversed by administration of vitamin K. It is suggested that some of the clotting factors known to be vitamin K-dependent also play a role in primary hemostasis; alternatively, a putative vascular 'bleeding factor' could be modulated by vitamin K availability.
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M3 - Article
C2 - 3945636
AN - SCOPUS:0022624779
SN - 0037-9727
VL - 181
SP - 275
EP - 276
JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
IS - 2
ER -