Progressive brachial plexus enlargement in hereditary transthyretin amyloidosis

Alessandro Salvalaggio, Daniele Coraci, Laura Obici, Mario Cacciavillani, Marco Luigetti, Anna Mazzeo, Francesca Pastorelli, Marina Grandis, Tiziana Cavallaro, Giulia Bisogni, Alessandro Lozza, Chiara Gemelli, Luca Gentile, Massimo Russo, Mario Ermani, Gian Maria Fabrizi, Rosaria Plasmati, Federica De Napoli, Marta Campagnolo, Francesca CastellaniFabrizio Salvi, Silvia Fenu, Grazia Devigili, Davide Pareyson, Roberto Gasparotti, Claudio Rapezzi, Carlo Martinoli, Luca Padua, Chiara Briani

Research output: Contribution to journalArticlepeer-review


Axonal polyneuropathy is the main feature of hereditary transthyretin amyloidosis (ATTRv). Nerve morphological abnormalities have been reported, but longitudinal changes have never been assessed. We performed a prospective widespread nerve ultrasound evaluation and nerve cross-sectional area (CSA) was compared with baseline data in both ATTRv patients and pre-symptomatic carriers. Thirty-eight subjects were evaluated (mean follow-up 17.1 months), among them 21 had polyneuropathy while 17 were pre-symptomatic carriers. CSA significantly increased at brachial plexus in both groups (p = 0.008 and p = 0.012) pointing to progressive brachial plexus enlargement as a longitudinal biomarker of both disease progression and disease occurrence in pre-symptomatic carriers.

Original languageEnglish
JournalJournal of Neurology
Publication statusAccepted/In press - 2021


  • Amyloidosis
  • Brachial plexus
  • Peripheral nerves
  • Transthyretin
  • Ultrasound

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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