Programmed cell death of myelin basic protein-specific T lymphocytes is reduced in patients with acute multiple sclerosis

Marina Saresella; Ivana Marventano; Livianna Speciale; Stefania Ruzzante; Daria Trabattoni; Silvia Della Bella; Massimo Filippi; Francesca Fasano; Rosella Cavarretta; Domenico Caputo; Mario Clerici; Pasquale Ferrante

doi:10.1016/j.jneuroim.2005.05.010

Programmed cell death of myelin basic protein-specific T lymphocytes is reduced in patients with acute multiple sclerosis

Marina Saresella, Ivana Marventano, Livianna Speciale, Stefania Ruzzante, Daria Trabattoni, Silvia Della Bella, Massimo Filippi, Francesca Fasano, Rosella Cavarretta, Domenico Caputo, Mario Clerici, Pasquale Ferrante

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the apoptosis of myelin basic protein (MBP)-specific T lymphocytes in multiple sclerosis (MS) patients with acute (AMS) or stable (SMS) MS by evaluating the expression of apoptosis markers on peripheral cells. Cells of healthy controls (HC) were evaluated as well. Results showed that mitogen-stimulated apoptosis was comparable among patients and controls, whereas MBP-stimulated CD4+ and CD8+ 7-AAD+ and 7-AAD+ Fas+ cell (apoptotic cells) were significantly reduced in AMS patients. A reduction of the apoptotic rate of myelin-specific CD4+ and CD8+ T lymphocytes could be involved in the immune-mediated destruction of the myelin sheath seen in AMS patients.

Original language	English
Pages (from-to)	173-179
Number of pages	7
Journal	Journal of Neuroimmunology
Volume	166
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2005.05.010
Publication status	Published - Sept 2005

Keywords

Apoptosis
Immunology
Multiple sclerosis
Myelin basic protein
T lymphocyte

ASJC Scopus subject areas

Immunology
Clinical Neurology
Immunology and Allergy
Neurology

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10.1016/j.jneuroim.2005.05.010

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Saresella, M., Marventano, I., Speciale, L., Ruzzante, S., Trabattoni, D., Della Bella, S., Filippi, M., Fasano, F., Cavarretta, R., Caputo, D., Clerici, M., & Ferrante, P. (2005). Programmed cell death of myelin basic protein-specific T lymphocytes is reduced in patients with acute multiple sclerosis. Journal of Neuroimmunology, 166(1-2), 173-179. https://doi.org/10.1016/j.jneuroim.2005.05.010

Saresella, M , Marventano, I, Speciale, L, Ruzzante, S, Trabattoni, D, Della Bella, S , Filippi, M, Fasano, F, Cavarretta, R, Caputo, D, Clerici, M & Ferrante, P 2005, 'Programmed cell death of myelin basic protein-specific T lymphocytes is reduced in patients with acute multiple sclerosis', Journal of Neuroimmunology, vol. 166, no. 1-2, pp. 173-179. https://doi.org/10.1016/j.jneuroim.2005.05.010

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title = "Programmed cell death of myelin basic protein-specific T lymphocytes is reduced in patients with acute multiple sclerosis",

abstract = "We investigated the apoptosis of myelin basic protein (MBP)-specific T lymphocytes in multiple sclerosis (MS) patients with acute (AMS) or stable (SMS) MS by evaluating the expression of apoptosis markers on peripheral cells. Cells of healthy controls (HC) were evaluated as well. Results showed that mitogen-stimulated apoptosis was comparable among patients and controls, whereas MBP-stimulated CD4+ and CD8+ 7-AAD+ and 7-AAD+ Fas+ cell (apoptotic cells) were significantly reduced in AMS patients. A reduction of the apoptotic rate of myelin-specific CD4+ and CD8+ T lymphocytes could be involved in the immune-mediated destruction of the myelin sheath seen in AMS patients.",

keywords = "Apoptosis, Immunology, Multiple sclerosis, Myelin basic protein, T lymphocyte",

author = "Marina Saresella and Ivana Marventano and Livianna Speciale and Stefania Ruzzante and Daria Trabattoni and {Della Bella}, Silvia and Massimo Filippi and Francesca Fasano and Rosella Cavarretta and Domenico Caputo and Mario Clerici and Pasquale Ferrante",

year = "2005",

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doi = "10.1016/j.jneuroim.2005.05.010",

language = "English",

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AU - Saresella, Marina

AU - Marventano, Ivana

AU - Speciale, Livianna

AU - Ruzzante, Stefania

AU - Trabattoni, Daria

AU - Della Bella, Silvia

AU - Filippi, Massimo

AU - Fasano, Francesca

AU - Cavarretta, Rosella

AU - Caputo, Domenico

AU - Clerici, Mario

AU - Ferrante, Pasquale

PY - 2005/9

Y1 - 2005/9

N2 - We investigated the apoptosis of myelin basic protein (MBP)-specific T lymphocytes in multiple sclerosis (MS) patients with acute (AMS) or stable (SMS) MS by evaluating the expression of apoptosis markers on peripheral cells. Cells of healthy controls (HC) were evaluated as well. Results showed that mitogen-stimulated apoptosis was comparable among patients and controls, whereas MBP-stimulated CD4+ and CD8+ 7-AAD+ and 7-AAD+ Fas+ cell (apoptotic cells) were significantly reduced in AMS patients. A reduction of the apoptotic rate of myelin-specific CD4+ and CD8+ T lymphocytes could be involved in the immune-mediated destruction of the myelin sheath seen in AMS patients.

AB - We investigated the apoptosis of myelin basic protein (MBP)-specific T lymphocytes in multiple sclerosis (MS) patients with acute (AMS) or stable (SMS) MS by evaluating the expression of apoptosis markers on peripheral cells. Cells of healthy controls (HC) were evaluated as well. Results showed that mitogen-stimulated apoptosis was comparable among patients and controls, whereas MBP-stimulated CD4+ and CD8+ 7-AAD+ and 7-AAD+ Fas+ cell (apoptotic cells) were significantly reduced in AMS patients. A reduction of the apoptotic rate of myelin-specific CD4+ and CD8+ T lymphocytes could be involved in the immune-mediated destruction of the myelin sheath seen in AMS patients.

KW - Apoptosis

KW - Immunology

KW - Multiple sclerosis

KW - Myelin basic protein

KW - T lymphocyte

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Programmed cell death of myelin basic protein-specific T lymphocytes is reduced in patients with acute multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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