TY - JOUR
T1 - Prognostic value of the PIK3CA, AKT, and PTEN mutations in oral squamous cell carcinoma
T2 - Literature review
AU - Starzyńska, Anna
AU - Sejda, Aleksandra
AU - Adamska, Paulina
AU - Marvaso, Giulia
AU - Sakowicz-Burkiewicz, Monika
AU - Adamski, Łukasz
AU - Jereczek-Fossa, Barbara A.
N1 - Publisher Copyright:
© 2020 Termedia & Banach.
PY - 2021
Y1 - 2021
N2 - Over 260,000 (2013) new oral squamous cell carcinoma (OSCC) cases are reported annually worldwide. Despite development in OSCC management, the outcome is still unsatisfactory. Identification of new molecular markers may be of use in prevention, prognosis, and choice of an appropriate therapy. The intracellular molecular signalling pathway of phosphatidyl-inositol-3-kinase is involved in the process of cell growth, differentiation, migration, and survival. The main components of this pathway: PIK3CA (phosphatidylinositol- 4,5-bisphosphate-3-kinase catalytic subunit α), PTEN (phosphatase and tensin homologue deleted on chromosome 10), and AKT (serine-threonine kinase) are potential objects of research when introducing new therapeutic agents. The aim of this paper is to evaluate the PIK3CA, PTEN, and AKT gene mutations as prognostic factors in OSCC and to describe their role in aggressive disease progression. This is crucial for oral cancer biology understanding and for indicating which direction new clinical treatments should take.
AB - Over 260,000 (2013) new oral squamous cell carcinoma (OSCC) cases are reported annually worldwide. Despite development in OSCC management, the outcome is still unsatisfactory. Identification of new molecular markers may be of use in prevention, prognosis, and choice of an appropriate therapy. The intracellular molecular signalling pathway of phosphatidyl-inositol-3-kinase is involved in the process of cell growth, differentiation, migration, and survival. The main components of this pathway: PIK3CA (phosphatidylinositol- 4,5-bisphosphate-3-kinase catalytic subunit α), PTEN (phosphatase and tensin homologue deleted on chromosome 10), and AKT (serine-threonine kinase) are potential objects of research when introducing new therapeutic agents. The aim of this paper is to evaluate the PIK3CA, PTEN, and AKT gene mutations as prognostic factors in OSCC and to describe their role in aggressive disease progression. This is crucial for oral cancer biology understanding and for indicating which direction new clinical treatments should take.
KW - AKT
KW - Oral squamous cell carcinoma
KW - PIK3CA
KW - PTEN
UR - http://www.scopus.com/inward/record.url?scp=85103557741&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85103557741&partnerID=8YFLogxK
U2 - 10.5114/aoms.2020.100780
DO - 10.5114/aoms.2020.100780
M3 - Review article
AN - SCOPUS:85103557741
SN - 1734-1922
VL - 17
SP - 207
EP - 217
JO - Archives of Medical Science
JF - Archives of Medical Science
IS - 1
ER -