Prognostic value of myocardial perfusion scintigraphy in elderly patients with hypertension: A 10-year follow-up analysis

Luca Nai Fovino, Giorgio Saladini, Anna Rita Cervino, Francesca Saladini, Michele Gregianin, Renato Razzolini, Laura Evangelista

Research output: Contribution to journalArticlepeer-review


Purpose The aim of the study was to assess the role of myocardial perfusion scintigraphy (MPS) in the prediction of future cardiac events in elderly hypertensive patients and to investigate if its prognostic value is maintained during a 10-year follow-up period. Methods A total of 229 consecutive patients = 65 years old (range 65-88 years) with arterial hypertension, who were referred to our institution for stress/rest 99mTc-sestamibi MPS between January 2000 and November 2001, were followed up for 10-12 years. Cardiac death, myocardial infarction and a coronary revascularization procedure were considered as events. Survival curves were computed by the Kaplan-Meier method. A stepwise Cox proportional hazards analysis was used to identify predictors of events. Results Follow-up was completed in 221 (96.5 %) patients; 26 patients experienced cardiac death, 29 myocardial infarction and 51 coronary revascularization. Annual event rates for cardiac death, cardiac death/myocardial infarction and cardiac death/myocardial infarction/coronary revascularization were, respectively, 0, 0.2 and 0.4 % for patients with a normal scan and 1.5, 3.0 and 5.3 % after an abnormal MPS. Event-free survival was significantly different according to extent and severity of perfusion defects (all p

Original languageEnglish
Pages (from-to)1570-1580
Number of pages11
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Issue number10
Publication statusPublished - Oct 2012


  • Cardiac events
  • Elderly patients
  • Hypertension
  • Myocardial perfusion scintigraphy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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