Prognostic impact of pregnancy after breast cancer according to estrogen receptor status: A multicenter retrospective study

Hatem A. Azim, Niels Kroman, Marianne Paesmans, Shari Gelber, Nicole Rotmensz, Lieveke Ameye, Leticia De Mattos-Arruda, Barbara Pistilli, Alvaro Pinto, Maj Britt Jensen, Octavi Cordoba, Evandro De Azambuja, Aron Goldhirsch, Martine J. Piccart, Fedro A. Peccatori

Research output: Contribution to journalArticlepeer-review


Purpose: We questioned the impact of pregnancy on disease-free survival (DFS) in women with history of breast cancer (BC) according to estrogen receptor (ER) status. Patients and Methods: A multicenter, retrospective cohort study in which patients who became pregnant any time after BC were matched (1:3) to patients with BC with similar ER, nodal status, adjuvant therapy, age, and year of diagnosis. To adjust for guaranteed time bias, each nonpregnant patient had to have a disease-free interval at least equal to the time elapsing between BC diagnosis and date of conception of the matched pregnant one. The primary objective was DFS in patients with ER-positive BC. DFS in the ER-negative cohort, whole population, and overall survival (OS) were secondary objectives. Subgroup analyses included DFS according to pregnancy outcome and BC-pregnancy interval. With a two-sided α = 5% and β = 20%, 645 ER-positive patients were required to detect a hazard ratio (HR) = 0.65. Results: A total of 333 pregnant patients and 874 matched nonpregnant patients were analyzed, of whom 686 patients had an ER-positive disease. No difference in DFS was observed between pregnant and nonpregnant patients in the ER-positive (HR = 0.91; 95% CI, 0.67 to 1.24, P = .55) or the ER-negative (HR = 0.75; 95% CI, 0.51 to 1.08, P = .12) cohorts. However, the pregnant group had better OS (HR = 0.72; 95% CI, 0.54 to 0.97, P = .03), with no interaction according to ER status (P = .11). Pregnancy outcome and BC-pregnancy interval did not seem to impact the risk of relapse. Conclusion: Pregnancy after ER-positive BC does not seem to reduce the risk of BC recurrence.

Original languageEnglish
Pages (from-to)73-79
Number of pages7
JournalJournal of Clinical Oncology
Issue number1
Publication statusPublished - Jan 1 2013

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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