Prognostic Impact of Node-Spreading Pattern in Surgically Treated Small-Cell Lung Cancer: A Multicentric Analysis.

Giovanni Leuzzi; Filippo Lococo; Gabriele Alessandrini; Isabella Sperduti; Lorenzo Spaggiari; Federico Venuta; Erino A. Rendina; Pierluigi M. Granone; Cristian Rapicetta; Piero Zannini; Gaetano Di Rienzo; Maurizio Nicolosi; Francesco Facciolo

doi:10.1007/s00408-016-9954-4

Prognostic Impact of Node-Spreading Pattern in Surgically Treated Small-Cell Lung Cancer: A Multicentric Analysis.

Giovanni Leuzzi, Filippo Lococo, Gabriele Alessandrini, Isabella Sperduti, Lorenzo Spaggiari, Federico Venuta, Erino A. Rendina, Pierluigi M. Granone, Cristian Rapicetta, Piero Zannini, Gaetano Di Rienzo, Maurizio Nicolosi, Francesco Facciolo

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: Although surgery in selected small-cell lung cancer (SCLC) patients has been proposed as a part of multimodality therapy, so far, the prognostic impact of node-spreading pattern has not been fully elucidated. To investigate this issue, a retrospective analysis was performed. METHODS: From 01/1996 to 12/2012, clinico-pathological, surgical, and oncological features were retrospectively reviewed in a multicentric cohort of 154 surgically treated SCLC patients. A multivariate Cox proportional hazard model was developed using stepwise regression, in order to identify independent outcome predictors. Overall (OS), cancer-specific (CSS), and Relapse-free survival (RFS) were calculated by Kaplan-Meier method. RESULTS: Overall, median OS, CSS, and RFS were 29 (95 % CI

Original language	Undefined/Unknown
Pages (from-to)	107-114
Number of pages	8
Journal	Lung
Volume	195
Issue number	1
DOIs	https://doi.org/10.1007/s00408-016-9954-4
Publication status	Published - Feb 1 2017

Keywords

Lymphadenectomy, Multimodality therapy, Node-spreading pattern, Ratio, Small-cell lung cancer, Surgery

Access to Document

10.1007/s00408-016-9954-4

Cite this

Leuzzi, G., Lococo, F., Alessandrini, G., Sperduti, I., Spaggiari, L., Venuta, F., Rendina, E. A., Granone, P. M., Rapicetta, C., Zannini, P., Di Rienzo, G., Nicolosi, M., & Facciolo, F. (2017). Prognostic Impact of Node-Spreading Pattern in Surgically Treated Small-Cell Lung Cancer: A Multicentric Analysis. Lung, 195(1), 107-114. https://doi.org/10.1007/s00408-016-9954-4

Leuzzi, G , Lococo, F , Alessandrini, G , Sperduti, I , Spaggiari, L, Venuta, F, Rendina, EA, Granone, PM, Rapicetta, C, Zannini, P, Di Rienzo, G, Nicolosi, M & Facciolo, F 2017, 'Prognostic Impact of Node-Spreading Pattern in Surgically Treated Small-Cell Lung Cancer: A Multicentric Analysis.', Lung, vol. 195, no. 1, pp. 107-114. https://doi.org/10.1007/s00408-016-9954-4

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title = "Prognostic Impact of Node-Spreading Pattern in Surgically Treated Small-Cell Lung Cancer: A Multicentric Analysis.",

abstract = "OBJECTIVE: Although surgery in selected small-cell lung cancer (SCLC) patients has been proposed as a part of multimodality therapy, so far, the prognostic impact of node-spreading pattern has not been fully elucidated. To investigate this issue, a retrospective analysis was performed. METHODS: From 01/1996 to 12/2012, clinico-pathological, surgical, and oncological features were retrospectively reviewed in a multicentric cohort of 154 surgically treated SCLC patients. A multivariate Cox proportional hazard model was developed using stepwise regression, in order to identify independent outcome predictors. Overall (OS), cancer-specific (CSS), and Relapse-free survival (RFS) were calculated by Kaplan-Meier method. RESULTS: Overall, median OS, CSS, and RFS were 29 (95 % CI",

keywords = "Lymphadenectomy, Multimodality therapy, Node-spreading pattern, Ratio, Small-cell lung cancer, Surgery",

author = "Giovanni Leuzzi and Filippo Lococo and Gabriele Alessandrini and Isabella Sperduti and Lorenzo Spaggiari and Federico Venuta and Rendina, {Erino A.} and Granone, {Pierluigi M.} and Cristian Rapicetta and Piero Zannini and {Di Rienzo}, Gaetano and Maurizio Nicolosi and Francesco Facciolo",

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doi = "10.1007/s00408-016-9954-4",

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T1 - Prognostic Impact of Node-Spreading Pattern in Surgically Treated Small-Cell Lung Cancer: A Multicentric Analysis.

AU - Leuzzi, Giovanni

AU - Lococo, Filippo

AU - Alessandrini, Gabriele

AU - Sperduti, Isabella

AU - Spaggiari, Lorenzo

AU - Venuta, Federico

AU - Rendina, Erino A.

AU - Granone, Pierluigi M.

AU - Rapicetta, Cristian

AU - Zannini, Piero

AU - Di Rienzo, Gaetano

AU - Nicolosi, Maurizio

AU - Facciolo, Francesco

PY - 2017/2/1

Y1 - 2017/2/1

N2 - OBJECTIVE: Although surgery in selected small-cell lung cancer (SCLC) patients has been proposed as a part of multimodality therapy, so far, the prognostic impact of node-spreading pattern has not been fully elucidated. To investigate this issue, a retrospective analysis was performed. METHODS: From 01/1996 to 12/2012, clinico-pathological, surgical, and oncological features were retrospectively reviewed in a multicentric cohort of 154 surgically treated SCLC patients. A multivariate Cox proportional hazard model was developed using stepwise regression, in order to identify independent outcome predictors. Overall (OS), cancer-specific (CSS), and Relapse-free survival (RFS) were calculated by Kaplan-Meier method. RESULTS: Overall, median OS, CSS, and RFS were 29 (95 % CI

AB - OBJECTIVE: Although surgery in selected small-cell lung cancer (SCLC) patients has been proposed as a part of multimodality therapy, so far, the prognostic impact of node-spreading pattern has not been fully elucidated. To investigate this issue, a retrospective analysis was performed. METHODS: From 01/1996 to 12/2012, clinico-pathological, surgical, and oncological features were retrospectively reviewed in a multicentric cohort of 154 surgically treated SCLC patients. A multivariate Cox proportional hazard model was developed using stepwise regression, in order to identify independent outcome predictors. Overall (OS), cancer-specific (CSS), and Relapse-free survival (RFS) were calculated by Kaplan-Meier method. RESULTS: Overall, median OS, CSS, and RFS were 29 (95 % CI

KW - Lymphadenectomy, Multimodality therapy, Node-spreading pattern, Ratio, Small-cell lung cancer, Surgery

U2 - 10.1007/s00408-016-9954-4

DO - 10.1007/s00408-016-9954-4

M3 - Articolo

SN - 0341-2040

VL - 195

SP - 107

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JO - Lung

JF - Lung

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