Prognostic features of endometrial cancer in estrogen users and obese women

Carlo La Vecchia, Silvia Franceschi, Giuseppe Gallus, Adriano Decarli, Elena Colombo, Alessandro Liberati, Gianni Tognoni

Research output: Contribution to journalArticlepeer-review


In a case-control study to evaluate risk factors for endometrial cancer in Italy, use of noncontraceptive estrogens was associated with a moderately increased risk, whereas obesity appeared to be the most important single risk factor related to cancer of the endometrium. This report considers the estrogen and obesity-related relative risks with regard to various prognostic features of tumors (clinical stage, histologic grade, extent of myometrial invasion, lymph node involvement). In both estrogen users and obese women, the increase in relative risk was greater for earlier than for more advanced tumors. These findings, therefore, provide further support for a specific role of both exogenous and endogenous estrogens in endometrial cancer.

Original languageEnglish
Pages (from-to)387-390
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Issue number4
Publication statusPublished - Oct 15 1982

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology


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