Prognostic factors of gastrointestinal stromal tumors

Drazen Kovac; Mladen Petrovecki; Mladen Jasic; Renata Dobi-Babic; Nikola Ivanis; Milivoj Rubinic; Simun Krizanac; Nives Jonjic; Clara Rizzardi; Mauro Melato

Prognostic factors of gastrointestinal stromal tumors

Drazen Kovac, Mladen Petrovecki, Mladen Jasic, Renata Dobi-Babic, Nikola Ivanis, Milivoj Rubinic, Simun Krizanac, Nives Jonjic, Clara Rizzardi, Mauro Melato

IRCCS pediatrico Burlo Garofolo

Research output: Contribution to journal › Article › peer-review

Abstract

Gastrointestinal stromal tumors (GIST) are rare neoplasms of unknown etiology and pathogenesis. Their clinical behavior is very unpredictable and a reliable prognostic factor is lacking. The aim of this study was to analyze some prognostic factors and estimate which one is the most reliable. Thirty-eight biopsy specimens of GIST were immunolabeled for PCNA, CD34, vimentin, NSE and actin. The greatest diameter, histological grading, mitotic count, DNA-index and S-phase were estimated for each case. All patients were followed-up for at least 24 months or to death. The data were analysed by univariate and multivariate statistical analysis using a computer program. The results showed that greatest diameter, tumor grade, mitotic count and PCNA-index are prognostic factors in univariate analysis. In multivariate analysis only the greatest diameter is a useful prognostic factor for planning further therapy.

Original language	English
Pages (from-to)	1913-1917
Number of pages	5
Journal	Anticancer Research
Volume	22
Issue number	3
Publication status	Published - 2002

Keywords

Flow-cytometry
GIST
Intestine
Prognosis
Stomach

ASJC Scopus subject areas

Cancer Research
Oncology

Cite this

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title = "Prognostic factors of gastrointestinal stromal tumors",

abstract = "Gastrointestinal stromal tumors (GIST) are rare neoplasms of unknown etiology and pathogenesis. Their clinical behavior is very unpredictable and a reliable prognostic factor is lacking. The aim of this study was to analyze some prognostic factors and estimate which one is the most reliable. Thirty-eight biopsy specimens of GIST were immunolabeled for PCNA, CD34, vimentin, NSE and actin. The greatest diameter, histological grading, mitotic count, DNA-index and S-phase were estimated for each case. All patients were followed-up for at least 24 months or to death. The data were analysed by univariate and multivariate statistical analysis using a computer program. The results showed that greatest diameter, tumor grade, mitotic count and PCNA-index are prognostic factors in univariate analysis. In multivariate analysis only the greatest diameter is a useful prognostic factor for planning further therapy.",

keywords = "Flow-cytometry, GIST, Intestine, Prognosis, Stomach",

author = "Drazen Kovac and Mladen Petrovecki and Mladen Jasic and Renata Dobi-Babic and Nikola Ivanis and Milivoj Rubinic and Simun Krizanac and Nives Jonjic and Clara Rizzardi and Mauro Melato",

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T1 - Prognostic factors of gastrointestinal stromal tumors

AU - Kovac, Drazen

AU - Petrovecki, Mladen

AU - Jasic, Mladen

AU - Dobi-Babic, Renata

AU - Ivanis, Nikola

AU - Rubinic, Milivoj

AU - Krizanac, Simun

AU - Jonjic, Nives

AU - Rizzardi, Clara

AU - Melato, Mauro

PY - 2002

Y1 - 2002

N2 - Gastrointestinal stromal tumors (GIST) are rare neoplasms of unknown etiology and pathogenesis. Their clinical behavior is very unpredictable and a reliable prognostic factor is lacking. The aim of this study was to analyze some prognostic factors and estimate which one is the most reliable. Thirty-eight biopsy specimens of GIST were immunolabeled for PCNA, CD34, vimentin, NSE and actin. The greatest diameter, histological grading, mitotic count, DNA-index and S-phase were estimated for each case. All patients were followed-up for at least 24 months or to death. The data were analysed by univariate and multivariate statistical analysis using a computer program. The results showed that greatest diameter, tumor grade, mitotic count and PCNA-index are prognostic factors in univariate analysis. In multivariate analysis only the greatest diameter is a useful prognostic factor for planning further therapy.

AB - Gastrointestinal stromal tumors (GIST) are rare neoplasms of unknown etiology and pathogenesis. Their clinical behavior is very unpredictable and a reliable prognostic factor is lacking. The aim of this study was to analyze some prognostic factors and estimate which one is the most reliable. Thirty-eight biopsy specimens of GIST were immunolabeled for PCNA, CD34, vimentin, NSE and actin. The greatest diameter, histological grading, mitotic count, DNA-index and S-phase were estimated for each case. All patients were followed-up for at least 24 months or to death. The data were analysed by univariate and multivariate statistical analysis using a computer program. The results showed that greatest diameter, tumor grade, mitotic count and PCNA-index are prognostic factors in univariate analysis. In multivariate analysis only the greatest diameter is a useful prognostic factor for planning further therapy.

KW - Flow-cytometry

KW - GIST

KW - Intestine

KW - Prognosis

KW - Stomach

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JO - Anticancer Research

JF - Anticancer Research

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ER -

Prognostic factors of gastrointestinal stromal tumors

Abstract

Keywords

ASJC Scopus subject areas

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