Prognostic Factors in Node-Negative Breast Cancer

Houston Johnson; Shahla Masood; Claudio Belluco; Abdel Moneim Abou Azama; Supranee Dee; Leonard Kahn; Leslie Wise

doi:10.1001/archsurg.1992.01420120020003

Prognostic Factors in Node-Negative Breast Cancer

Houston Johnson, Shahla Masood, Claudio Belluco, Abdel Moneim Abou Azama, Supranee Dee, Leonard Kahn, Leslie Wise

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article › peer-review

Abstract

One hundred patients with node-negative breast cancer were examined to analyze the influence of tumor size, nuclear grade, and DNA content determined by flow cytometry on overall survival. Patients with diploid cancers lived significantly longer than those with aneuploid cancers (126±8 vs 80±11 months). Patients with an S-phase fraction less than 10% lived significantly longer than those with S-phase fractions 10% or greater (122±8 vs 85±10 months). Tumor size had the major impact on survival, and multivariate analysis of variance by the Cox proportional hazards model showed the greatest effect on prognosis. Tumor grade did not significantly influence overall survival.

Original language	English
Pages (from-to)	1386-1391
Number of pages	6
Journal	Archives of Surgery
Volume	127
Issue number	12
DOIs	https://doi.org/10.1001/archsurg.1992.01420120020003
Publication status	Published - 1992

ASJC Scopus subject areas

Surgery

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10.1001/archsurg.1992.01420120020003

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title = "Prognostic Factors in Node-Negative Breast Cancer",

abstract = "One hundred patients with node-negative breast cancer were examined to analyze the influence of tumor size, nuclear grade, and DNA content determined by flow cytometry on overall survival. Patients with diploid cancers lived significantly longer than those with aneuploid cancers (126±8 vs 80±11 months). Patients with an S-phase fraction less than 10% lived significantly longer than those with S-phase fractions 10% or greater (122±8 vs 85±10 months). Tumor size had the major impact on survival, and multivariate analysis of variance by the Cox proportional hazards model showed the greatest effect on prognosis. Tumor grade did not significantly influence overall survival.",

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T1 - Prognostic Factors in Node-Negative Breast Cancer

AU - Johnson, Houston

AU - Masood, Shahla

AU - Belluco, Claudio

AU - Abou Azama, Abdel Moneim

AU - Dee, Supranee

AU - Kahn, Leonard

AU - Wise, Leslie

PY - 1992

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N2 - One hundred patients with node-negative breast cancer were examined to analyze the influence of tumor size, nuclear grade, and DNA content determined by flow cytometry on overall survival. Patients with diploid cancers lived significantly longer than those with aneuploid cancers (126±8 vs 80±11 months). Patients with an S-phase fraction less than 10% lived significantly longer than those with S-phase fractions 10% or greater (122±8 vs 85±10 months). Tumor size had the major impact on survival, and multivariate analysis of variance by the Cox proportional hazards model showed the greatest effect on prognosis. Tumor grade did not significantly influence overall survival.

AB - One hundred patients with node-negative breast cancer were examined to analyze the influence of tumor size, nuclear grade, and DNA content determined by flow cytometry on overall survival. Patients with diploid cancers lived significantly longer than those with aneuploid cancers (126±8 vs 80±11 months). Patients with an S-phase fraction less than 10% lived significantly longer than those with S-phase fractions 10% or greater (122±8 vs 85±10 months). Tumor size had the major impact on survival, and multivariate analysis of variance by the Cox proportional hazards model showed the greatest effect on prognosis. Tumor grade did not significantly influence overall survival.

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Prognostic Factors in Node-Negative Breast Cancer

Abstract

ASJC Scopus subject areas

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