Prognostic factors in multidisciplinary rehabilitation treatment in multiple sclerosis: An outcome study

Maria Grazia Grasso, E. Troisi, F. Rizzi, D. Morelli, S. Paolucci

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The aim of this outcome study was to evaluate the effectiveness and prognostic factors of inpatient multidisciplinary rehabilitation treatment in patients with multiple sclerosis (MS). We analysed 230 consecutive inpatients with MS admitted to an MS rehabilitation ward who followed an individualized, goal-oriented, multidisciplinary rehabilitation program. Every patient was submitted to a neurological examination and evaluated by means of Kurtzke's Expanded Disability Status Scale (EDSS), with its functional systems (FS), Barthel Index (BI) and the Rivermead Mobility Index (RMI). We observed an effectiveness (percentage of potential improvement achieved during rehabilitation) of nearly 16% on BI and 8% on RMI, corresponding to an improvement in 124 patients (54%) on BI and 113 patients (49%) on RMI. Basal EDSS (β =-0.32, P 2 =0.176), whereas effectiveness on RMI was correlated only with the EDSS score (β = -0.34, P 2 =0.113). In the logistic regression analysis, the absence of severe sphincteric disturbances was correlated with the probability of improvement on BI that was nearly twice as high (OR = 2.25, 95% CI 1.24-4.08) as that of other patients. Moreover, patients without severe cognitive deficits showed a similar probability (OR = 2.37, 95% CI 1.05-5.33) of improvement on RMI. The results of this study provide further evidence that intensive multidisciplinary rehabilitation in MS is effective in the majority of MS patients and that early treatment may favour functional recovery.

Original languageEnglish
Pages (from-to)719-724
Number of pages6
JournalMultiple Sclerosis Journal
Issue number6
Publication statusPublished - Dec 2005


  • Multiple sclerosis
  • Prognostic factors
  • Rehabilitation

ASJC Scopus subject areas

  • Clinical Neurology


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