Progesterone receptor immunoreactivity in minute meningothelioid nodules of the lung

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Meningothelioid nodules (MNs) are not uncommon lesions of the pulmonary interstitium composed of monomorphic round to spindle cells, likely reactive in nature. Their origin is unsettled, though a derivation from arachnoid-like cells in conditions of perturbed perfusion of the pulmonary tissue has been proposed. Here we confirm the consistent occurrence of intense progesterone-receptor immunoreactivity in MNs fortuitously detected in surgical specimens of lung carcinomas. This finding corroborates the view that these proliferations exhibit arachnoid cell-like differentiation and suggests a role for sex-steroid hormones in the control of their growth.

Original languageEnglish
Pages (from-to)543-546
Number of pages4
JournalVirchows Archiv
Issue number5
Publication statusPublished - 2002


  • Immunohistochemistry
  • Lung
  • Meningothelioid nodule
  • Progesterone receptors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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