Pro-apoptotic activity of cyclopentenone in cancer cells

M. Rosetti; M. Frasnelli; F. Fabbri; C. Arienti; I. Vannini; A. Tesei; W. Zoli; M. Conti

Pro-apoptotic activity of cyclopentenone in cancer cells

M. Rosetti, M. Frasnelli, F. Fabbri, C. Arienti, I. Vannini, A. Tesei, W. Zoli, M. Conti

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Studies on cyclopentenone prostaglandins (CPPGs), clavulones and other cyclopentenones have shown that these compounds have a significant anticancer activity mediated by their cyclopentenone (CP) chemical moiety. In this study the cytotoxicity against cancer cells of the model compound cyclopent-2-en-1-one (2CP) was investigated. Being a highly water soluble small molecule, 2CP could be an ideal candidate to overcome pharmacological issues related to drug delivery and penetration. Its cytotoxic activity was tested on various melanoma and lung cancer cells. Interestingly, 2CP was both cytotoxic and pro-apoptotic, more pronounced on melanoma cells, at concentrations in the sub-micromolar range. On melanoma cells its mechanism of action was mediated by the mitochondria and the activation of caspase 3.

Original language	English
Pages (from-to)	315-320
Number of pages	6
Journal	Anticancer Research
Volume	28
Issue number	1 A
Publication status	Published - Jan 2008

Keywords

Apoptosis
Cyclopentenone
Cytotoxicity
Mitochondria

ASJC Scopus subject areas

Cancer Research
Oncology

Cite this

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abstract = "Studies on cyclopentenone prostaglandins (CPPGs), clavulones and other cyclopentenones have shown that these compounds have a significant anticancer activity mediated by their cyclopentenone (CP) chemical moiety. In this study the cytotoxicity against cancer cells of the model compound cyclopent-2-en-1-one (2CP) was investigated. Being a highly water soluble small molecule, 2CP could be an ideal candidate to overcome pharmacological issues related to drug delivery and penetration. Its cytotoxic activity was tested on various melanoma and lung cancer cells. Interestingly, 2CP was both cytotoxic and pro-apoptotic, more pronounced on melanoma cells, at concentrations in the sub-micromolar range. On melanoma cells its mechanism of action was mediated by the mitochondria and the activation of caspase 3.",

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AU - Rosetti, M.

AU - Frasnelli, M.

AU - Fabbri, F.

AU - Arienti, C.

AU - Vannini, I.

AU - Tesei, A.

AU - Zoli, W.

AU - Conti, M.

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AB - Studies on cyclopentenone prostaglandins (CPPGs), clavulones and other cyclopentenones have shown that these compounds have a significant anticancer activity mediated by their cyclopentenone (CP) chemical moiety. In this study the cytotoxicity against cancer cells of the model compound cyclopent-2-en-1-one (2CP) was investigated. Being a highly water soluble small molecule, 2CP could be an ideal candidate to overcome pharmacological issues related to drug delivery and penetration. Its cytotoxic activity was tested on various melanoma and lung cancer cells. Interestingly, 2CP was both cytotoxic and pro-apoptotic, more pronounced on melanoma cells, at concentrations in the sub-micromolar range. On melanoma cells its mechanism of action was mediated by the mitochondria and the activation of caspase 3.

KW - Apoptosis

KW - Cyclopentenone

KW - Cytotoxicity

KW - Mitochondria

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Pro-apoptotic activity of cyclopentenone in cancer cells

Abstract

Keywords

ASJC Scopus subject areas

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