Primary peripheral PNET/Ewing's sarcoma arising in the meninges, confirmed by the presence of the rare translocation t(21;22) (q22;q12)

Manila Antonelli; Rosario Caltabiano; Caterina Chiappetta; Maria A. Oliva; Felice Giangaspero; Salvatore Lanzafame

doi:10.1111/j.1440-1789.2010.01196.x

Primary peripheral PNET/Ewing's sarcoma arising in the meninges, confirmed by the presence of the rare translocation t(21;22) (q22;q12)

Manila Antonelli, Rosario Caltabiano, Caterina Chiappetta, Maria A. Oliva, Felice Giangaspero, Salvatore Lanzafame

www.neuromed.it

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Abstract

Peripheral primitive neuroectodermal tumor/Ewing's sarcoma (ES) (pPNET/ES) of intracranial origin are very rare. These tumors are characterized by specific translocations involving a gene on chromosome 22q12, the most common being t(11;22) (q24;q12). We report a case of 37-year-old man with pPNET/ES arising in the meninges and bearing the rare translocation t(21;22) (q22;q12). The tumor was composed of sheets and nests of monotonous small cells with round to oval nuclei, finely dispersed chromatin, small nucleolus and scant cytoplasm. We discuss the importance of the differential diagnosis with central primitive neuroectodermal tumors (cPNET).

Original language	English
Pages (from-to)	549-555
Number of pages	7
Journal	Neuropathology
Volume	31
Issue number	5
DOIs	https://doi.org/10.1111/j.1440-1789.2010.01196.x
Publication status	Published - Oct 2011

Keywords

CD99
Ewing's sarcoma
Meninges
Primitive neuroectodermal tumor
T(21;22) (q22;q12)

ASJC Scopus subject areas

Pathology and Forensic Medicine
Clinical Neurology

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10.1111/j.1440-1789.2010.01196.x

Cite this

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title = "Primary peripheral PNET/Ewing's sarcoma arising in the meninges, confirmed by the presence of the rare translocation t(21;22) (q22;q12)",

abstract = "Peripheral primitive neuroectodermal tumor/Ewing's sarcoma (ES) (pPNET/ES) of intracranial origin are very rare. These tumors are characterized by specific translocations involving a gene on chromosome 22q12, the most common being t(11;22) (q24;q12). We report a case of 37-year-old man with pPNET/ES arising in the meninges and bearing the rare translocation t(21;22) (q22;q12). The tumor was composed of sheets and nests of monotonous small cells with round to oval nuclei, finely dispersed chromatin, small nucleolus and scant cytoplasm. We discuss the importance of the differential diagnosis with central primitive neuroectodermal tumors (cPNET).",

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author = "Manila Antonelli and Rosario Caltabiano and Caterina Chiappetta and Oliva, {Maria A.} and Felice Giangaspero and Salvatore Lanzafame",

year = "2011",

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doi = "10.1111/j.1440-1789.2010.01196.x",

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AU - Caltabiano, Rosario

AU - Chiappetta, Caterina

AU - Oliva, Maria A.

AU - Giangaspero, Felice

AU - Lanzafame, Salvatore

PY - 2011/10

Y1 - 2011/10

N2 - Peripheral primitive neuroectodermal tumor/Ewing's sarcoma (ES) (pPNET/ES) of intracranial origin are very rare. These tumors are characterized by specific translocations involving a gene on chromosome 22q12, the most common being t(11;22) (q24;q12). We report a case of 37-year-old man with pPNET/ES arising in the meninges and bearing the rare translocation t(21;22) (q22;q12). The tumor was composed of sheets and nests of monotonous small cells with round to oval nuclei, finely dispersed chromatin, small nucleolus and scant cytoplasm. We discuss the importance of the differential diagnosis with central primitive neuroectodermal tumors (cPNET).

AB - Peripheral primitive neuroectodermal tumor/Ewing's sarcoma (ES) (pPNET/ES) of intracranial origin are very rare. These tumors are characterized by specific translocations involving a gene on chromosome 22q12, the most common being t(11;22) (q24;q12). We report a case of 37-year-old man with pPNET/ES arising in the meninges and bearing the rare translocation t(21;22) (q22;q12). The tumor was composed of sheets and nests of monotonous small cells with round to oval nuclei, finely dispersed chromatin, small nucleolus and scant cytoplasm. We discuss the importance of the differential diagnosis with central primitive neuroectodermal tumors (cPNET).

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KW - T(21;22) (q22;q12)

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Primary peripheral PNET/Ewing's sarcoma arising in the meninges, confirmed by the presence of the rare translocation t(21;22) (q22;q12)

Abstract

Keywords

ASJC Scopus subject areas

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