Primary ovarian insufficiency: X chromosome defects and autoimmunity

Luca Persani, Raffaella Rossetti, Chiara Cacciatore, Marco Bonomi

Research output: Contribution to journalArticlepeer-review


Premature ovarian failure (POF) is a primary ovarian defect characterized by absent menarche or premature depletion of ovarian follicles before the age of 40 years. However, in several instances the distinction between definitive or intermittent POF may be difficult on clinical bases, therefore the more appropriate term Primary Ovarian Insufficiency (POI) has been recently proposed and will be used in this review. POI is a heterogeneous disorder affecting approximately 1% of women

Original languageEnglish
Pages (from-to)35-41
Number of pages7
JournalJournal of Autoimmunity
Issue number1
Publication statusPublished - Aug 2009


  • Amenorrhea
  • Autoimmune oophoritis
  • BMP15
  • FMR1
  • Folliculogenesis
  • Hypergonadotropic ovarian failure
  • Ovarian dysgenesis
  • Premature ovarian failure
  • Primary ovarian insufficiency
  • Turner syndrome
  • X chromosome

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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