Primary lymph node gastrinoma: A case report and review of the literature

Elisabetta Cavalcanti, Elisa Stasi, Sergio Coletta, Dionigi Lorusso, Caterina Mammone Rinaldi, Raffaele Armentano

Research output: Contribution to journalArticlepeer-review


Background: Gastrinoma is a rare form of neuroendocrine neoplasm. The presence of a primary lymph node localization of gastrinoma is a much debated and controversial topic in the literature, as regards whether these cases represent metastatic disease from an as yet unidentified primary tumor, or the de novo occurrence of a gastrinoma in a lymph node. Case presentation: We report the case of a 24-year-old male with intense epigastric pain treated at the beginning with high dose proton pump inhibitors. Further workup with CT and subsequent laparotomy revealed a single peripancreatic lymph node. Histological examination highlighted a well-differentiated neuroendocrine tumor. Conclusion: This case underlines that the primitive lymph node gastrinoma is a distinct nosological entity with a precise location in the context of rare neuroendocrine tumors that should be considered when specific symptoms are associated with the identification of isolated lymph nodes, after excluding any possible primitive locations of neoplastic localization.

Original languageEnglish
Article number80
JournalWorld Journal of Surgical Oncology
Issue number1
Publication statusPublished - Apr 28 2020


  • Gastrinoma
  • NEN (neuroendocrine neoplasm)
  • Primitive lymph node

ASJC Scopus subject areas

  • Surgery
  • Oncology


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