Primary CNS demyelinating diseases in childhood: Multiple sclerosis

P. Iannetti, M. G. Marciani, A. Spalice, F. Spanedda, U. Raucci, G. Trasimeni, G. F. Gualdi, G. Bernardi

Research output: Contribution to journalArticlepeer-review


We report on five children (three female and two male, age span 11-16 years) with laboratory supported definite multiple sclerosis or clinically definite multiple sclerosis, diagnosed on the basis of Poser and Paty criteria. All patients were subjected to serial clinical examinations, magnetic resonance investigations, CSF biochemical and immunological studies, and neurophysiological and neuropsychological assessments. Four of the five examined subjects underwent steroid treatment. Over a period of 3 years relapses have been observed in three of them. The first symptoms and signs of multiple sclerosis may be subtle and misleading; careful assessment of them may be crucial for an early diagnosis of the disease.

Original languageEnglish
Pages (from-to)149-154
Number of pages6
JournalChild's Nervous System
Issue number3
Publication statusPublished - Mar 1996


  • Childhood
  • Demyelinating diseases
  • Multiple sclerosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


Dive into the research topics of 'Primary CNS demyelinating diseases in childhood: Multiple sclerosis'. Together they form a unique fingerprint.

Cite this