TY - JOUR
T1 - Primary and secondary prevention of stroke by antihypertensive treatment in clinical trials
AU - Grassi, Guido
AU - Arenare, Francesca
AU - Trevano, Fosca Quarti
AU - Dell'Oro, Raffaella
AU - Mancia, Giuseppe
PY - 2007/8
Y1 - 2007/8
N2 - High blood pressure represents one of the leading risk factors for the development of stroke and its recurrence. This explains why blood pressure control is a major objective of antihypertensive treatment, both in primary and secondary prevention of this cerebrovascular disease. This paper reviews the evidence provided by randomized clinical trials on the favorable effects exerted by blood pressure reduction on this end point. Emphasis is given to the results of recently published clinical trials documenting that drugs acting on the renin-angiotensin system may exert cerebrovascular protective effects additive to the ones associated with blood pressure reduction.
AB - High blood pressure represents one of the leading risk factors for the development of stroke and its recurrence. This explains why blood pressure control is a major objective of antihypertensive treatment, both in primary and secondary prevention of this cerebrovascular disease. This paper reviews the evidence provided by randomized clinical trials on the favorable effects exerted by blood pressure reduction on this end point. Emphasis is given to the results of recently published clinical trials documenting that drugs acting on the renin-angiotensin system may exert cerebrovascular protective effects additive to the ones associated with blood pressure reduction.
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U2 - 10.1007/s11906-007-0055-x
DO - 10.1007/s11906-007-0055-x
M3 - Article
C2 - 17686381
AN - SCOPUS:34548499309
SN - 1522-6417
VL - 9
SP - 299
EP - 304
JO - Current Hypertension Reports
JF - Current Hypertension Reports
IS - 4
ER -