Preventing adverse obstetric outcomes in women with genetic thrombophilia

Elvira Grandone, Vincenzo Brancaccio, Donatella Colaizzo, Natale Sciannamé, Giuseppe Pavone, Giovanni Di Minno, Maurizio Margaglione

Research output: Contribution to journalArticlepeer-review


Objective: To improve fetomaternal outcomes in women with obstetric complications and inherited causes of thrombophilia. Design: Clinical trial. Setting: Thrombophilic women with previous unexplained adverse outcomes. Patient(s): Twenty-five women with previous severe obstetric complications were treated during and after pregnancy. Intervention(s): Low fixed dose of heparin or aspirin. Main Outcome Measure(s): Fetomaternal outcome. Result(s): Low fixed dose of heparin were administered to 24 pregnant women, aspirin to 7. Overall, among 31 treated pregnant women, 28 (90.3%) compared to 4 of 58 (6.9%) in previous pregnancies had a good obstetric outcome. Two fetal losses

Original languageEnglish
Pages (from-to)371-375
Number of pages5
JournalFertility and Sterility
Issue number2
Publication statusPublished - 2002


  • Pregnancy complications
  • Thrombophilia
  • Thromboprophylaxis

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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