Prevalence of HIV infection in 646 heroin addicts and outcome of HIV-related conditions in the 266 followed up

C. Mandelli; D. Conte; R. Barbera; T. Masullo; S. Pistoso; G. P. Aimo; L. Cesarini; M. Fraguelli; G. P. Lorini; P. A. Bianchi

doi:10.1007/BF00221346

Prevalence of HIV infection in 646 heroin addicts and outcome of HIV-related conditions in the 266 followed up

C. Mandelli, D. Conte, R. Barbera, T. Masullo, S. Pistoso, G. P. Aimo, L. Cesarini, M. Fraguelli, G. P. Lorini, P. A. Bianchi

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

In a series of 646 heroin addicts anti-HIV was detected in 428 (66.2%) and HBsAg in 53 (8.2%). Forty-eight (90.5%) of the latter had concomitant chronic HDV infection. Markers of past HBV infection were found in 481 (74.4%). The prevalence of anti-HIV was significantly higher in the 534 subjects with HBV markers than in the other 112 without markers (69.8% versus 49.1%, p <0.001). Of the 266 anti-HIV positive subjects followed for 3-48 months (median 12), nine progressed from no disease to persistent generalized lymphadenopathy (PGL), 52 from PGL to AIDS-related complex (ARC) or AIDS (30 and 22 cases respectively), and six from ARC to AIDS. Baseline T4 + cell count was significantly lower and reduction during follow-up significantly greater in heroin addicts with disease progression than in those without.

Original language	English
Pages (from-to)	83-87
Number of pages	5
Journal	European Journal of Epidemiology
Volume	7
Issue number	1
DOIs	https://doi.org/10.1007/BF00221346
Publication status	Published - Jan 1991

Keywords

AIDS
AIDS-related complex (ARC)
Hepatitis B
Hepatitis delta
Heroin users
HIV

ASJC Scopus subject areas

Epidemiology

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10.1007/BF00221346

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title = "Prevalence of HIV infection in 646 heroin addicts and outcome of HIV-related conditions in the 266 followed up",

abstract = "In a series of 646 heroin addicts anti-HIV was detected in 428 (66.2%) and HBsAg in 53 (8.2%). Forty-eight (90.5%) of the latter had concomitant chronic HDV infection. Markers of past HBV infection were found in 481 (74.4%). The prevalence of anti-HIV was significantly higher in the 534 subjects with HBV markers than in the other 112 without markers (69.8% versus 49.1%, p <0.001). Of the 266 anti-HIV positive subjects followed for 3-48 months (median 12), nine progressed from no disease to persistent generalized lymphadenopathy (PGL), 52 from PGL to AIDS-related complex (ARC) or AIDS (30 and 22 cases respectively), and six from ARC to AIDS. Baseline T4 + cell count was significantly lower and reduction during follow-up significantly greater in heroin addicts with disease progression than in those without.",

keywords = "AIDS, AIDS-related complex (ARC), Hepatitis B, Hepatitis delta, Heroin users, HIV",

author = "C. Mandelli and D. Conte and R. Barbera and T. Masullo and S. Pistoso and Aimo, {G. P.} and L. Cesarini and M. Fraguelli and Lorini, {G. P.} and Bianchi, {P. A.}",

year = "1991",

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doi = "10.1007/BF00221346",

language = "English",

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T1 - Prevalence of HIV infection in 646 heroin addicts and outcome of HIV-related conditions in the 266 followed up

AU - Mandelli, C.

AU - Conte, D.

AU - Barbera, R.

AU - Masullo, T.

AU - Pistoso, S.

AU - Aimo, G. P.

AU - Cesarini, L.

AU - Fraguelli, M.

AU - Lorini, G. P.

AU - Bianchi, P. A.

PY - 1991/1

Y1 - 1991/1

N2 - In a series of 646 heroin addicts anti-HIV was detected in 428 (66.2%) and HBsAg in 53 (8.2%). Forty-eight (90.5%) of the latter had concomitant chronic HDV infection. Markers of past HBV infection were found in 481 (74.4%). The prevalence of anti-HIV was significantly higher in the 534 subjects with HBV markers than in the other 112 without markers (69.8% versus 49.1%, p <0.001). Of the 266 anti-HIV positive subjects followed for 3-48 months (median 12), nine progressed from no disease to persistent generalized lymphadenopathy (PGL), 52 from PGL to AIDS-related complex (ARC) or AIDS (30 and 22 cases respectively), and six from ARC to AIDS. Baseline T4 + cell count was significantly lower and reduction during follow-up significantly greater in heroin addicts with disease progression than in those without.

AB - In a series of 646 heroin addicts anti-HIV was detected in 428 (66.2%) and HBsAg in 53 (8.2%). Forty-eight (90.5%) of the latter had concomitant chronic HDV infection. Markers of past HBV infection were found in 481 (74.4%). The prevalence of anti-HIV was significantly higher in the 534 subjects with HBV markers than in the other 112 without markers (69.8% versus 49.1%, p <0.001). Of the 266 anti-HIV positive subjects followed for 3-48 months (median 12), nine progressed from no disease to persistent generalized lymphadenopathy (PGL), 52 from PGL to AIDS-related complex (ARC) or AIDS (30 and 22 cases respectively), and six from ARC to AIDS. Baseline T4 + cell count was significantly lower and reduction during follow-up significantly greater in heroin addicts with disease progression than in those without.

KW - AIDS

KW - AIDS-related complex (ARC)

KW - Hepatitis B

KW - Hepatitis delta

KW - Heroin users

KW - HIV

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Prevalence of HIV infection in 646 heroin addicts and outcome of HIV-related conditions in the 266 followed up

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Keywords

ASJC Scopus subject areas

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