Abstract
Background: Older patients are prone to multimorbidity and polypharmacy, with an inherent risk of adverse events and drug interactions. To the best of our knowledge, available information on the appropriateness of lipid-lowering treatment is extremely limited. Aim: The aim of the present study was to quantify and characterize lipid-lowering drug use in a population of complex in-hospital older patients. Methods: We analyzed data from 87 units of internal medicine or geriatric medicine in the REPOSI (Registro Politerapie della Società Italiana di Medicina Interna) study, with reference to the 2010 and 2012 patient cohorts. Lipid-lowering drug use was closely correlated with the clinical profiles, including multimorbidity markers and polypharmacy. Results: 2171 patients aged >65 years were enrolled (1057 males, 1114 females, mean age 78.6 years). The patients treated with lipid-lowering drugs amounted to 508 subjects (23.4%), with no gender difference. Atorvastatin (39.3%) and simvastatin (34.0%) were the most widely used statin drugs. Likelihood of treatment was associated with polypharmacy (≥5 drugs) and with higher Cumulative Illness Rating Scale (CIRS) score. At logistic regression analysis, the presence of coronary heart disease, peripheral vascular disease, and hypertension were significantly correlated with lipid-lowering drug use, whereas age showed an inverse correlation. Diabetes was not associated with drug treatment. Conclusions: In this in-hospital cohort, the use of lipid-lowering agents was mainly driven by patients’ clinical history, most notably the presence of clinically overt manifestations of atherosclerosis. Increasing age seems to be associated with lower prescription rates. This might be indicative of cautious behavior towards a potentially toxic treatment regimen.
| Original language | English |
|---|---|
| Pages (from-to) | 311-319 |
| Number of pages | 9 |
| Journal | Drugs and Aging |
| Volume | 34 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 1 2017 |
ASJC Scopus subject areas
- Geriatrics and Gerontology
- Pharmacology (medical)
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Prevalence and Determinants of the Use of Lipid-Lowering Agents in a Population of Older Hospitalized Patients : the Findings from the REPOSI (REgistro POliterapie Società Italiana di Medicina Interna) Study. / Bertolotti, Marco; Franchi, Carlotta; Rocchi, Marco B.L. et al.
In: Drugs and Aging, Vol. 34, No. 4, 01.04.2017, p. 311-319.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Prevalence and Determinants of the Use of Lipid-Lowering Agents in a Population of Older Hospitalized Patients
T2 - the Findings from the REPOSI (REgistro POliterapie Società Italiana di Medicina Interna) Study
AU - Bertolotti, Marco
AU - Franchi, Carlotta
AU - Rocchi, Marco B.L.
AU - Miceli, Andrea
AU - Libbra, M. Vittoria
AU - Nobili, Alessandro
AU - Lancellotti, Giulia
AU - Carulli, Lucia
AU - Mussi, Chiara
AU - Mannucci, Pier Mannuccio
AU - Tettamanti, Mauro
AU - Pasina, Luca
AU - Perticone, Francesco
AU - Salerno, Francesco
AU - Corrao, Salvatore
AU - Marengoni, Alessandra
AU - Licata, Giuseppe
AU - Violi, Francesco
AU - Corazza, Gino Roberto
AU - Marcucci, Maura
AU - Eldin, Tarek Kamal
AU - Di Blanca, Maria Pia Donatella
AU - Lanzo, Giovanna
AU - Astuto, Sarah
AU - Ardoino, Ilaria
AU - Cortesi, Laura
AU - Prisco, Domenico
AU - Silvestri, Elena
AU - Cenci, Caterina
AU - Emmi, Giacomo
AU - Biolo, Gianni
AU - Guarnieri, Gianfranco
AU - Zanetti, Michela
AU - Fernandes, Giovanni
AU - Chiuch, Massimiliano
AU - Vanoli, Massimo
AU - Grignani, Giulia
AU - Casella, Gianluca
AU - Pulixi, Edoardo Alessandro
AU - Bernardi, Mauro
AU - Bassi, Silvia Li
AU - Santi, Luca
AU - Zaccherini, Giacomo
AU - Mannarino, Elmo
AU - Lupattelli, Graziana
AU - Bianconi, Vanessa
AU - Paciullo, Francesco
AU - Nuti, Ranuccio
AU - Valenti, Roberto
AU - Ruvio, Martina
AU - Cappelli, Silvia
AU - Palazzuoli, Alberto
AU - Salvatore, Teresa
AU - Sasso, Ferdinando Carlo
AU - Girelli, Domenico
AU - Olivieri, Oliviero
AU - Matteazzi, Thomas
AU - Barbagallo, Mario
AU - Plances, Lidia
AU - Alcamo, Roberta
AU - Calvo, Luigi
AU - Valenti, Maria
AU - Pasini, Franco Laghi
AU - Capecchi, Pier Leopoldo
AU - Bicchi, Maurizio
AU - Palasciano, Giuseppe
AU - Modeo, Maria Ester
AU - Peragine, Maria
AU - Pappagallo, Fabrizio
AU - Pugliese, Stefania
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AU - Postiglione, Alfredo
AU - Barbella, Maria Rosaria
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AU - Cappellini, Maria Domenica
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AU - Seghezzi, Sonia
AU - De Amicis, Margherita Migone
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AU - Ottolini, Barbara Brignolo
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AU - Miceli, Emanuela
AU - Lenti, Marco Vincenzo
AU - Padula, Donatella
AU - Murialdo, Giovanni
AU - Marra, Alessio
AU - Cattaneo, Federico
AU - Secchi, Maria Beatrice
AU - Ghelfi, Davide
AU - Anastasio, Luigi
AU - Sofia, Lucia
AU - Carbone, Maria
AU - Davì, Giovanni
AU - Guagnano, Maria Teresa
AU - Sestili, Simona
AU - Mancuso, Gerardo
AU - Calipari, Daniela
AU - Bartone, Mosè
AU - Meroni, Maria Rachele
AU - Perin, Paolo Cavallo
AU - Lorenzati, Bartolomeo
AU - Gruden, Gabriella
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AU - Tiraboschi, Slivia
AU - Peyvandi, Flora
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AU - Ferrari, Barbara
AU - Monzani, Valter
AU - Savojardo, Valeria
AU - Folli, Christian
AU - Salerno, Maria Magnini Francesco
AU - Conca, Alessio
AU - Gobbo, Giulia
AU - Pallini, Giada
AU - Valenti, Miriam
AU - Balduini, Carlo L.
AU - Bertolino, Giampiera
AU - Provini, Stella
AU - Quaglia, Federica
AU - Dallegri, Franco
AU - Ottonello, Luciano
AU - Liberale, Luca
AU - Chin, Wu Sheng
AU - Carassale, Laura
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AU - De Feudis, Lucrezia
AU - Di Carlo, Silvia
AU - Liberato, Nicola Lucio
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AU - Bianchi, Giovanni Battista
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AU - Cavallaro, Federica
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AU - Favorini, Serena
AU - Col, Anna Dal
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AU - Afeltra, Antonella
AU - Alemanno, Pamela
AU - Marigliano, Benedetta
AU - Pipita, Maria Elena
AU - Castellino, Pietro
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AU - Zanoli, Luca
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AU - Gioffrè, Vincenza
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AU - Scattolin, Giuseppe
AU - Martinelli, Sergio
AU - Turrin, Mauro
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AU - Catena, Cristina
AU - Colussi, Gianluca
AU - Nieves, Ramirez Duque
AU - Alberto, Muela Molinero
AU - Pedro, Abad Requejo
AU - Vanessa, Lopez Pelaez
AU - Lara, Tamargo
AU - Xavier, Corbella Viros
AU - Francesc, Formiga
AU - Jesus, Diez Manglano
AU - Esperanza, Bejarano Tello
AU - Esther, Del Corral Behamonte
AU - Maria, Sevil Puras
AU - Romero, Manuel
AU - Blanca, Pinilla Llorente
AU - Cristina, Lopez Gonzalez Cobos
AU - Victoria, Villalba Garcia M.
AU - Saez, Lopez
AU - Bosco, Juan
AU - Susana, Sanz Baena
AU - Marta, Arroyo Gallego
AU - Concepcion, Gonzalez Becerra
AU - Antonio, Fernandez Moyano
AU - Hernandez, Mercedes Gomez
AU - Borrego, Manuel Poyato
AU - Raquel, Pacheco Cuadros
AU - Florencia, Perez Rojas
AU - Beatriz, Garcia Olid
AU - Sara, Carrascosa Garcia
AU - Alfonso, Gonzalez Cruz Cervellera
AU - Marta, Peinado Martinez
AU - Garcia, Sara Carrascosa
AU - Alberto, Ruiz Cantero
AU - Antonio, Albarracín Arraigosa
AU - Montserrat, Godoy Guerrero
AU - Ángel, Barón Ramos Miguel
AU - Manuel, Machin Jose
AU - Ignacio, Novo Veleiro
AU - Lucía, Alvela Suarez
AU - Alfonso, Lopez
AU - David, Rubal Bran
AU - Iria, Iñiguez Vazquez
AU - Monica, Rios Prego
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Background: Older patients are prone to multimorbidity and polypharmacy, with an inherent risk of adverse events and drug interactions. To the best of our knowledge, available information on the appropriateness of lipid-lowering treatment is extremely limited. Aim: The aim of the present study was to quantify and characterize lipid-lowering drug use in a population of complex in-hospital older patients. Methods: We analyzed data from 87 units of internal medicine or geriatric medicine in the REPOSI (Registro Politerapie della Società Italiana di Medicina Interna) study, with reference to the 2010 and 2012 patient cohorts. Lipid-lowering drug use was closely correlated with the clinical profiles, including multimorbidity markers and polypharmacy. Results: 2171 patients aged >65 years were enrolled (1057 males, 1114 females, mean age 78.6 years). The patients treated with lipid-lowering drugs amounted to 508 subjects (23.4%), with no gender difference. Atorvastatin (39.3%) and simvastatin (34.0%) were the most widely used statin drugs. Likelihood of treatment was associated with polypharmacy (≥5 drugs) and with higher Cumulative Illness Rating Scale (CIRS) score. At logistic regression analysis, the presence of coronary heart disease, peripheral vascular disease, and hypertension were significantly correlated with lipid-lowering drug use, whereas age showed an inverse correlation. Diabetes was not associated with drug treatment. Conclusions: In this in-hospital cohort, the use of lipid-lowering agents was mainly driven by patients’ clinical history, most notably the presence of clinically overt manifestations of atherosclerosis. Increasing age seems to be associated with lower prescription rates. This might be indicative of cautious behavior towards a potentially toxic treatment regimen.
AB - Background: Older patients are prone to multimorbidity and polypharmacy, with an inherent risk of adverse events and drug interactions. To the best of our knowledge, available information on the appropriateness of lipid-lowering treatment is extremely limited. Aim: The aim of the present study was to quantify and characterize lipid-lowering drug use in a population of complex in-hospital older patients. Methods: We analyzed data from 87 units of internal medicine or geriatric medicine in the REPOSI (Registro Politerapie della Società Italiana di Medicina Interna) study, with reference to the 2010 and 2012 patient cohorts. Lipid-lowering drug use was closely correlated with the clinical profiles, including multimorbidity markers and polypharmacy. Results: 2171 patients aged >65 years were enrolled (1057 males, 1114 females, mean age 78.6 years). The patients treated with lipid-lowering drugs amounted to 508 subjects (23.4%), with no gender difference. Atorvastatin (39.3%) and simvastatin (34.0%) were the most widely used statin drugs. Likelihood of treatment was associated with polypharmacy (≥5 drugs) and with higher Cumulative Illness Rating Scale (CIRS) score. At logistic regression analysis, the presence of coronary heart disease, peripheral vascular disease, and hypertension were significantly correlated with lipid-lowering drug use, whereas age showed an inverse correlation. Diabetes was not associated with drug treatment. Conclusions: In this in-hospital cohort, the use of lipid-lowering agents was mainly driven by patients’ clinical history, most notably the presence of clinically overt manifestations of atherosclerosis. Increasing age seems to be associated with lower prescription rates. This might be indicative of cautious behavior towards a potentially toxic treatment regimen.
UR - http://www.scopus.com/inward/record.url?scp=85015168921&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85015168921&partnerID=8YFLogxK
U2 - 10.1007/s40266-017-0448-8
DO - 10.1007/s40266-017-0448-8
M3 - Article
C2 - 28299634
AN - SCOPUS:85015168921
SN - 1170-229X
VL - 34
SP - 311
EP - 319
JO - Drugs and Aging
JF - Drugs and Aging
IS - 4
ER -