Prenatal treatment of congenital human cytomegalovirus infection by fetal intravascular administration of ganciclovir

M. Gracia Revello; Elena Percivalle; Fausto Baldanti; Giuseppe Gerna; Alessandra Kustermann; Simona Nava; Umberto Nicolini

doi:10.1016/0928-0197(93)90034-3

Prenatal treatment of congenital human cytomegalovirus infection by fetal intravascular administration of ganciclovir

M. Gracia Revello, Elena Percivalle, Fausto Baldanti, Giuseppe Gerna, Alessandra Kustermann, Simona Nava, Umberto Nicolini

Research output: Contribution to journal › Article › peer-review

Abstract

Ganciclovir was administered 'in utero' for 12 days in a 29-week-old fetus with ascertained congenital human cytomegalovirus (HCMV) infection, thrombocytopenia and elevated γ-glutamyl transferase (γGT) value. Efficacy of therapy was shown by reduction in virus titer of amniotic fluid and fetal urine, disappearance of viral DNA in fetal blood, and normalization of platelet count and γGT value. However, stillbirth occurred at 32 weeks of gestation and HCMV inclusion bodies were detected in kidneys, lungs, heart and pancreas at autopsy. During therapy, side-effects,possibly related to ganciclovir administration, were observed.

Original language	English
Pages (from-to)	61-67
Number of pages	7
Journal	Clinical and Diagnostic Virology
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/0928-0197(93)90034-3
Publication status	Published - 1993

Keywords

Ganciclovir
Human cytomegalovirus
Prenatal diagnosis
Prenatal treatment

ASJC Scopus subject areas

Virology

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10.1016/0928-0197(93)90034-3

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abstract = "Ganciclovir was administered 'in utero' for 12 days in a 29-week-old fetus with ascertained congenital human cytomegalovirus (HCMV) infection, thrombocytopenia and elevated γ-glutamyl transferase (γGT) value. Efficacy of therapy was shown by reduction in virus titer of amniotic fluid and fetal urine, disappearance of viral DNA in fetal blood, and normalization of platelet count and γGT value. However, stillbirth occurred at 32 weeks of gestation and HCMV inclusion bodies were detected in kidneys, lungs, heart and pancreas at autopsy. During therapy, side-effects,possibly related to ganciclovir administration, were observed.",

keywords = "Ganciclovir, Human cytomegalovirus, Prenatal diagnosis, Prenatal treatment",

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T1 - Prenatal treatment of congenital human cytomegalovirus infection by fetal intravascular administration of ganciclovir

AU - Gracia Revello, M.

AU - Percivalle, Elena

AU - Baldanti, Fausto

AU - Gerna, Giuseppe

AU - Kustermann, Alessandra

AU - Nava, Simona

AU - Nicolini, Umberto

PY - 1993

Y1 - 1993

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AB - Ganciclovir was administered 'in utero' for 12 days in a 29-week-old fetus with ascertained congenital human cytomegalovirus (HCMV) infection, thrombocytopenia and elevated γ-glutamyl transferase (γGT) value. Efficacy of therapy was shown by reduction in virus titer of amniotic fluid and fetal urine, disappearance of viral DNA in fetal blood, and normalization of platelet count and γGT value. However, stillbirth occurred at 32 weeks of gestation and HCMV inclusion bodies were detected in kidneys, lungs, heart and pancreas at autopsy. During therapy, side-effects,possibly related to ganciclovir administration, were observed.

KW - Ganciclovir

KW - Human cytomegalovirus

KW - Prenatal diagnosis

KW - Prenatal treatment

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Prenatal treatment of congenital human cytomegalovirus infection by fetal intravascular administration of ganciclovir

Abstract

Keywords

ASJC Scopus subject areas

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