Preliminary data on immunogenicity, safety and tolerability of trivalent inactivated influenza vaccine in children with inborn errors of metabolism at risk of decompensation

Susanna Esposito; Filippo Salvini; Francesca Menni; Alessia Scala; Elisabetta Salvatici; Francesca Manzoni; Enrica Riva; Marcello Giovannini; Nicola Principi

doi:10.1016/j.vaccine.2013.08.058

Preliminary data on immunogenicity, safety and tolerability of trivalent inactivated influenza vaccine in children with inborn errors of metabolism at risk of decompensation

Susanna Esposito, Filippo Salvini, Francesca Menni, Alessia Scala, Elisabetta Salvatici, Francesca Manzoni, Enrica Riva, Marcello Giovannini, Nicola Principi

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

In order to evaluate the immunogenicity, safety and tolerability of influenza vaccination in children with inborn errors of metabolism (IEMs), we enrolled 20 patients with IEMs at risk of decompensation (14 males; mean age. ±. SD, 8.5. ±. 3.9. years) and 20 healthy age- and gender-matched controls. Four weeks after vaccination, seroconversion rates were 75-85% and seroprotection rates 85-95%, with high geometric mean titers (GMTs) of all three influenza antigen strains in both groups. Three months after vaccination, most of the subjects remained seroconverted with high seroprotection rates and high GMTs for all the three influenza strains. Safety and tolerability were also very good, with no differences between the groups.

Original language	English
Pages (from-to)	5149-5151
Number of pages	3
Journal	Vaccine
Volume	31
Issue number	45
DOIs	https://doi.org/10.1016/j.vaccine.2013.08.058
Publication status	Published - Oct 25 2013

Keywords

Children
Influenza vaccine
Influenza virus
Metabolic disease
Trivalent influenza vaccine

ASJC Scopus subject areas

Immunology and Microbiology(all)
Infectious Diseases
Public Health, Environmental and Occupational Health
veterinary(all)
Molecular Medicine

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10.1016/j.vaccine.2013.08.058

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Esposito, S., Salvini, F., Menni, F., Scala, A., Salvatici, E., Manzoni, F., Riva, E., Giovannini, M., & Principi, N. (2013). Preliminary data on immunogenicity, safety and tolerability of trivalent inactivated influenza vaccine in children with inborn errors of metabolism at risk of decompensation. Vaccine, 31(45), 5149-5151. https://doi.org/10.1016/j.vaccine.2013.08.058

Esposito, S, Salvini, F, Menni, F, Scala, A, Salvatici, E, Manzoni, F, Riva, E, Giovannini, M & Principi, N 2013, 'Preliminary data on immunogenicity, safety and tolerability of trivalent inactivated influenza vaccine in children with inborn errors of metabolism at risk of decompensation', Vaccine, vol. 31, no. 45, pp. 5149-5151. https://doi.org/10.1016/j.vaccine.2013.08.058

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abstract = "In order to evaluate the immunogenicity, safety and tolerability of influenza vaccination in children with inborn errors of metabolism (IEMs), we enrolled 20 patients with IEMs at risk of decompensation (14 males; mean age. ±. SD, 8.5. ±. 3.9. years) and 20 healthy age- and gender-matched controls. Four weeks after vaccination, seroconversion rates were 75-85% and seroprotection rates 85-95%, with high geometric mean titers (GMTs) of all three influenza antigen strains in both groups. Three months after vaccination, most of the subjects remained seroconverted with high seroprotection rates and high GMTs for all the three influenza strains. Safety and tolerability were also very good, with no differences between the groups.",

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author = "Susanna Esposito and Filippo Salvini and Francesca Menni and Alessia Scala and Elisabetta Salvatici and Francesca Manzoni and Enrica Riva and Marcello Giovannini and Nicola Principi",

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AU - Esposito, Susanna

AU - Salvini, Filippo

AU - Menni, Francesca

AU - Scala, Alessia

AU - Salvatici, Elisabetta

AU - Manzoni, Francesca

AU - Riva, Enrica

AU - Giovannini, Marcello

AU - Principi, Nicola

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KW - Influenza virus

KW - Metabolic disease

KW - Trivalent influenza vaccine

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Preliminary data on immunogenicity, safety and tolerability of trivalent inactivated influenza vaccine in children with inborn errors of metabolism at risk of decompensation

Abstract

Keywords

ASJC Scopus subject areas

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