Pregnancy outcomes in pulmonary arterial hypertension in the modern management era

Xavier Jaïs, Karen M. Olsson, Joan A. Barbera, Isabel Blanco, Adam Torbicki, Andrew Peacock, C. Dario Vizza, Peter Macdonald, Marc Humbert, Marius M. Hoeper

Research output: Contribution to journalArticlepeer-review


Previous studies have reported mortality rates of up to 56% associated with pregnancy in pulmonary arterial hypertension (PAH) but the management of this disease has changed considerably in recent years. We compiled a multinational, prospective registry to examine the contemporary outcome of pregnancies in patients with PAH. During a 3-yr period, the 13 participating centres reported 26 pregnancies. Three (12%) females died and one (4%) developed right heart failure requiring urgent heart-lung transplantation. There were eight abortions; two spontaneous and six induced. 16 (62%) pregnancies were successful, i.e. the females delivered healthy babies without complications. These females had well controlled PAH (pulmonary vascular resistance (PVR) 500±352 dyn·s·cm-5); eight of them were long-term responders to calcium channel blockers. In contrast, the females who died or required transplantation had poorly controlled PAH (PVR 1,667±209 dyn·s·cm-5). Pregnancy remains associated with a substantial mortality rate in PAH. However, our results indicate that the outcome of pregnancy in PAH has improved, at least when PAH is well controlled, and particularly in long-term responders to calcium channel blockers. These data must be confirmed by larger series before the general recommendation to avoid pregnancy in all patients with PAH is reconsidered. Copyright

Original languageEnglish
Pages (from-to)881-885
Number of pages5
JournalEuropean Respiratory Journal
Issue number4
Publication statusPublished - Oct 1 2012


  • Hypertension
  • Pregnancy
  • Pulmonary
  • Right heart failure

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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