Predictors of Relapse after Discontinuing Systemic Treatment in Childhood Autoimmune Chronic Uveitis

Gabriele Simonini; Claudia Bracaglia; Marco Cattalini; Andrea Taddio; Alice Brambilla; Cinzia De Libero; Denise Pires Marafon; Roberto Caputo; Rolando Cimaz

doi:10.3899/jrheum.161336

Predictors of Relapse after Discontinuing Systemic Treatment in Childhood Autoimmune Chronic Uveitis

Gabriele Simonini, Claudia Bracaglia, Marco Cattalini, Andrea Taddio, Alice Brambilla, Cinzia De Libero, Denise Pires Marafon, Roberto Caputo, Rolando Cimaz

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To identify clinical predictors of relapse in childhood autoimmune chronic uveitis after stopping systemic treatment.

METHODS: A retrospective, multicenter, cohort study.

RESULTS: Ninety-four children in remission, receiving no treatments and with at least a 6-month followup, were enrolled. A higher probability of maintaining remission after discontinuing treatment was shown in idiopathic compared with juvenile idiopathic arthritis uveitis (Mantel-Cox chi-square = 23.21) if inactivity had been obtained within 6 months from starting systemic treatment (Mantel-Cox chi-square = 24.17) and by antitumor necrosis factor-α treatment (Mantel-Cox chi-square = 6.43).

CONCLUSION: Type of disease, time, and type of systemic therapy to achieve inactivity predict different duration of uveitis remission after treatment withdrawal.

Original language	English
Pages (from-to)	822-826
Number of pages	5
Journal	Journal of Rheumatology
Volume	44
Issue number	6
DOIs	https://doi.org/10.3899/jrheum.161336
Publication status	Published - Jun 2017

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title = "Predictors of Relapse after Discontinuing Systemic Treatment in Childhood Autoimmune Chronic Uveitis",

abstract = "OBJECTIVE: To identify clinical predictors of relapse in childhood autoimmune chronic uveitis after stopping systemic treatment.METHODS: A retrospective, multicenter, cohort study.RESULTS: Ninety-four children in remission, receiving no treatments and with at least a 6-month followup, were enrolled. A higher probability of maintaining remission after discontinuing treatment was shown in idiopathic compared with juvenile idiopathic arthritis uveitis (Mantel-Cox chi-square = 23.21) if inactivity had been obtained within 6 months from starting systemic treatment (Mantel-Cox chi-square = 24.17) and by antitumor necrosis factor-α treatment (Mantel-Cox chi-square = 6.43).CONCLUSION: Type of disease, time, and type of systemic therapy to achieve inactivity predict different duration of uveitis remission after treatment withdrawal.",

author = "Gabriele Simonini and Claudia Bracaglia and Marco Cattalini and Andrea Taddio and Alice Brambilla and {De Libero}, Cinzia and {Pires Marafon}, Denise and Roberto Caputo and Rolando Cimaz",

year = "2017",

month = jun,

doi = "10.3899/jrheum.161336",

language = "English",

volume = "44",

pages = "822--826",

journal = "Journal of Rheumatology",

issn = "0315-162X",

publisher = "Journal of Rheumatology",

number = "6",

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TY - JOUR

T1 - Predictors of Relapse after Discontinuing Systemic Treatment in Childhood Autoimmune Chronic Uveitis

AU - Simonini, Gabriele

AU - Bracaglia, Claudia

AU - Cattalini, Marco

AU - Taddio, Andrea

AU - Brambilla, Alice

AU - De Libero, Cinzia

AU - Pires Marafon, Denise

AU - Caputo, Roberto

AU - Cimaz, Rolando

PY - 2017/6

Y1 - 2017/6

N2 - OBJECTIVE: To identify clinical predictors of relapse in childhood autoimmune chronic uveitis after stopping systemic treatment.METHODS: A retrospective, multicenter, cohort study.RESULTS: Ninety-four children in remission, receiving no treatments and with at least a 6-month followup, were enrolled. A higher probability of maintaining remission after discontinuing treatment was shown in idiopathic compared with juvenile idiopathic arthritis uveitis (Mantel-Cox chi-square = 23.21) if inactivity had been obtained within 6 months from starting systemic treatment (Mantel-Cox chi-square = 24.17) and by antitumor necrosis factor-α treatment (Mantel-Cox chi-square = 6.43).CONCLUSION: Type of disease, time, and type of systemic therapy to achieve inactivity predict different duration of uveitis remission after treatment withdrawal.

AB - OBJECTIVE: To identify clinical predictors of relapse in childhood autoimmune chronic uveitis after stopping systemic treatment.METHODS: A retrospective, multicenter, cohort study.RESULTS: Ninety-four children in remission, receiving no treatments and with at least a 6-month followup, were enrolled. A higher probability of maintaining remission after discontinuing treatment was shown in idiopathic compared with juvenile idiopathic arthritis uveitis (Mantel-Cox chi-square = 23.21) if inactivity had been obtained within 6 months from starting systemic treatment (Mantel-Cox chi-square = 24.17) and by antitumor necrosis factor-α treatment (Mantel-Cox chi-square = 6.43).CONCLUSION: Type of disease, time, and type of systemic therapy to achieve inactivity predict different duration of uveitis remission after treatment withdrawal.

U2 - 10.3899/jrheum.161336

DO - 10.3899/jrheum.161336

M3 - Article

C2 - 28365583

SN - 0315-162X

VL - 44

SP - 822

EP - 826

JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 6

ER -

Predictors of Relapse after Discontinuing Systemic Treatment in Childhood Autoimmune Chronic Uveitis

Abstract

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