TY - JOUR
T1 - Predictors of immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma
T2 - A case report Clinical oncology
AU - Cattelan, Anna Maria
AU - Mattiolo, Adriana
AU - Grassi, Angela
AU - Piano, Maria Assunta
AU - Sasset, Lolita
AU - Trevenzoli, Marco
AU - Zanovello, Paola
AU - Calabrò, Maria Luisa
PY - 2016/2/3
Y1 - 2016/2/3
N2 - We present here a case of immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma (KS-IRIS) developed in an AIDS patient two months after initiation of antiretroviral therapy (ART). Baseline characteristics of this IRIS-KS case, within a cohort of 12 naïve AIDS-KS patients, were analyzed. No statistically significant differences in CD4 cell counts, plasma HIV RNA load, KS clinical staging, human herpesvirus 8 (HHV8) antibody titers and HHV8 load in peripheral blood mononuclear cells and saliva were evidenced. HHV8 load in plasma was found to be significantly higher in the KS-IRIS patient (> 6 log10 genome equivalents/ml, p = 0.01, t-test) compared to the 11 patients with KS regression. This case highlights that measurement of HHV8 load in plasma may be useful to identify patients at risk for KS-IRIS, and that this parameter should be included in the design of larger studies to define KS-IRIS risk predictors.
AB - We present here a case of immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma (KS-IRIS) developed in an AIDS patient two months after initiation of antiretroviral therapy (ART). Baseline characteristics of this IRIS-KS case, within a cohort of 12 naïve AIDS-KS patients, were analyzed. No statistically significant differences in CD4 cell counts, plasma HIV RNA load, KS clinical staging, human herpesvirus 8 (HHV8) antibody titers and HHV8 load in peripheral blood mononuclear cells and saliva were evidenced. HHV8 load in plasma was found to be significantly higher in the KS-IRIS patient (> 6 log10 genome equivalents/ml, p = 0.01, t-test) compared to the 11 patients with KS regression. This case highlights that measurement of HHV8 load in plasma may be useful to identify patients at risk for KS-IRIS, and that this parameter should be included in the design of larger studies to define KS-IRIS risk predictors.
KW - Biomarker
KW - HHV8
KW - Immune reconstitution inflammatory syndrome
KW - IRIS
KW - Kaposi's sarcoma
KW - KS
KW - KS-IRIS
KW - KSHV
UR - http://www.scopus.com/inward/record.url?scp=84957591861&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957591861&partnerID=8YFLogxK
U2 - 10.1186/s13027-016-0051-3
DO - 10.1186/s13027-016-0051-3
M3 - Article
AN - SCOPUS:84957591861
SN - 1750-9378
VL - 11
JO - Infectious Agents and Cancer
JF - Infectious Agents and Cancer
IS - 1
M1 - 5
ER -