Predicting progression in primary progressive multiple sclerosis: A 10-year multicenter study

Zhaleh Khaleeli, Oka Ciccatelli, Francesco Manfredonia, Frederik Barkhof, Bruno Brochet, Mata Cercignani, Vincent Dousset, Massimo Filippi, Xavier Montalban, Chris Polman, Marco Rovaris, Alex Rovira, Jaume Sastre-Garriga, Machteld Vellinga, David Miller, Alan Thompson

Research output: Contribution to journalArticlepeer-review


Rates of progression vary widely in primary progressive multiple sclerosis. This multicenter study aimed to identify predictors of progression over 10 years. A total of 101 patients who had been imaged at baseline and 2 years were scored on the expanded disability status scale after 10 years. Ordinal logistic regression identified the following independent variables that predicted progression: male sex, shorter disease duration, and slower timed walk test at baseline (best overall predictor), and deterioration in expanded disability status scale score and reduction in brain volume over 2 years. These predictors of long-term disability provide some insight into disease progression.

Original languageEnglish
Pages (from-to)790-793
Number of pages4
JournalAnnals of Neurology
Issue number6
Publication statusPublished - Jun 2008

ASJC Scopus subject areas

  • Neuroscience(all)


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