Predicting progression in primary progressive multiple sclerosis: A 10-year multicenter study

Zhaleh Khaleeli; Oka Ciccatelli; Francesco Manfredonia; Frederik Barkhof; Bruno Brochet; Mata Cercignani; Vincent Dousset; Massimo Filippi; Xavier Montalban; Chris Polman; Marco Rovaris; Alex Rovira; Jaume Sastre-Garriga; Machteld Vellinga; David Miller; Alan Thompson

doi:10.1002/ana.21375

Predicting progression in primary progressive multiple sclerosis: A 10-year multicenter study

Zhaleh Khaleeli, Oka Ciccatelli, Francesco Manfredonia, Frederik Barkhof, Bruno Brochet, Mata Cercignani, Vincent Dousset, Massimo Filippi, Xavier Montalban, Chris Polman, Marco Rovaris, Alex Rovira, Jaume Sastre-Garriga, Machteld Vellinga, David Miller, Alan Thompson

Research output: Contribution to journal › Article › peer-review

Abstract

Rates of progression vary widely in primary progressive multiple sclerosis. This multicenter study aimed to identify predictors of progression over 10 years. A total of 101 patients who had been imaged at baseline and 2 years were scored on the expanded disability status scale after 10 years. Ordinal logistic regression identified the following independent variables that predicted progression: male sex, shorter disease duration, and slower timed walk test at baseline (best overall predictor), and deterioration in expanded disability status scale score and reduction in brain volume over 2 years. These predictors of long-term disability provide some insight into disease progression.

Original language	English
Pages (from-to)	790-793
Number of pages	4
Journal	Annals of Neurology
Volume	63
Issue number	6
DOIs	https://doi.org/10.1002/ana.21375
Publication status	Published - Jun 2008

ASJC Scopus subject areas

Neuroscience(all)

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10.1002/ana.21375

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Khaleeli, Z., Ciccatelli, O., Manfredonia, F., Barkhof, F., Brochet, B., Cercignani, M., Dousset, V., Filippi, M., Montalban, X., Polman, C., Rovaris, M., Rovira, A., Sastre-Garriga, J., Vellinga, M., Miller, D., & Thompson, A. (2008). Predicting progression in primary progressive multiple sclerosis: A 10-year multicenter study. Annals of Neurology, 63(6), 790-793. https://doi.org/10.1002/ana.21375

Khaleeli, Z, Ciccatelli, O, Manfredonia, F, Barkhof, F, Brochet, B, Cercignani, M, Dousset, V, Filippi, M, Montalban, X, Polman, C, Rovaris, M, Rovira, A, Sastre-Garriga, J, Vellinga, M, Miller, D & Thompson, A 2008, 'Predicting progression in primary progressive multiple sclerosis: A 10-year multicenter study', Annals of Neurology, vol. 63, no. 6, pp. 790-793. https://doi.org/10.1002/ana.21375

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abstract = "Rates of progression vary widely in primary progressive multiple sclerosis. This multicenter study aimed to identify predictors of progression over 10 years. A total of 101 patients who had been imaged at baseline and 2 years were scored on the expanded disability status scale after 10 years. Ordinal logistic regression identified the following independent variables that predicted progression: male sex, shorter disease duration, and slower timed walk test at baseline (best overall predictor), and deterioration in expanded disability status scale score and reduction in brain volume over 2 years. These predictors of long-term disability provide some insight into disease progression.",

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AU - Khaleeli, Zhaleh

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AU - Manfredonia, Francesco

AU - Barkhof, Frederik

AU - Brochet, Bruno

AU - Cercignani, Mata

AU - Dousset, Vincent

AU - Filippi, Massimo

AU - Montalban, Xavier

AU - Polman, Chris

AU - Rovaris, Marco

AU - Rovira, Alex

AU - Sastre-Garriga, Jaume

AU - Vellinga, Machteld

AU - Miller, David

AU - Thompson, Alan

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Predicting progression in primary progressive multiple sclerosis: A 10-year multicenter study

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