Precision medicine into clinical practice: a web‐based tool enables real‐time pharmacogenetic assessment of tailored treatments in psychiatric disorders

Stefania Zampatti; Carlo Fabrizio; Michele Ragazzo; Giulia Campoli; Valerio Caputo; Claudia Strafella; Clelia Pellicano; Raffaella Cascella; Gianfranco Spalletta; Laura Petrosini; Carlo Caltagirone; Andrea Termine; Emiliano Giardina

doi:10.3390/jpm11090851

Precision medicine into clinical practice: a web‐based tool enables real‐time pharmacogenetic assessment of tailored treatments in psychiatric disorders

Stefania Zampatti, Carlo Fabrizio, Michele Ragazzo, Giulia Campoli, Valerio Caputo, Claudia Strafella, Clelia Pellicano, Raffaella Cascella, Gianfranco Spalletta, Laura Petrosini, Carlo Caltagirone, Andrea Termine, Emiliano Giardina

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

The management of neuropsychiatric disorders involves different pharmacological treatments. In order to perform efficacious drug treatments, the metabolism of CYP genes can help to foresee potential drug–drug interactions. The NeuroPGx software is an open‐source web‐based tool for genotype/diplotype/phenotype interpretation for neuropharmacogenomic purposes. The software provides information about: (i) the genotypes of evaluated SNPs (single nucleotide polymorphisms); (ii) the main diplotypes in CYP genes and corresponding metabolization phenotypes; (iii) the list of neuropsychiatric drugs with recommended dosage adjustment (according to CPIC and DPWG guidelines); (iv) the list of possible (rare) diplotypes and corresponding metabolization phenotypes. The combined application of NeuroPGx software to the OpenArray technology results in an easy, quick, and highly automated device ready to be used in routine clinical practice.

Original language	English
Article number	851
Journal	Journal of Personalized Medicine
Volume	11
Issue number	9
DOIs	https://doi.org/10.3390/jpm11090851
Publication status	Published - Sept 2021

Keywords

NeuroPGx
OpenArray
Pharmacogenomic
Software

ASJC Scopus subject areas

Medicine (miscellaneous)

Access to Document

10.3390/jpm11090851

Cite this

Zampatti, S., Fabrizio, C., Ragazzo, M., Campoli, G., Caputo, V., Strafella, C., Pellicano, C., Cascella, R., Spalletta, G., Petrosini, L., Caltagirone, C., Termine, A., & Giardina, E. (2021). Precision medicine into clinical practice: a web‐based tool enables real‐time pharmacogenetic assessment of tailored treatments in psychiatric disorders. Journal of Personalized Medicine, 11(9), [851]. https://doi.org/10.3390/jpm11090851

Zampatti, S, Fabrizio, C, Ragazzo, M, Campoli, G, Caputo, V, Strafella, C, Pellicano, C, Cascella, R, Spalletta, G, Petrosini, L, Caltagirone, C, Termine, A & Giardina, E 2021, 'Precision medicine into clinical practice: a web‐based tool enables real‐time pharmacogenetic assessment of tailored treatments in psychiatric disorders', Journal of Personalized Medicine, vol. 11, no. 9, 851. https://doi.org/10.3390/jpm11090851

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AU - Caltagirone, Carlo

AU - Termine, Andrea

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Precision medicine into clinical practice: a web‐based tool enables real‐time pharmacogenetic assessment of tailored treatments in psychiatric disorders

Abstract

Keywords

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