Pre-existing arterial stiffness can predict hypotension during induction of anaesthesia in the elderly

C. Alecu, E. Cuignet-Royer, P. M. Mertes, P. Salvi, H. Vespignani, M. Lambert, H. Bouaziz, A. Benetos

Research output: Contribution to journalArticlepeer-review


Background. The aim of the present study was to establish whether elevated carotid-femoral pulse wave velocity (c-fPWV), an indicator of aortic stiffness, assessed before surgery, is correlated with variations in arterial pressure (AP) during induction of anaesthesia in elderly patients undergoing non-cardiovascular surgery.Methodsc-fPWV was measured with the PulsePen® device during pre-surgical anaesthetic evaluation. Monitoring included electrocardiography, pulse oximetry, non-invasive AP, heart rate, bispectral index (BIS), and oxygen concentration during induction of anaesthesia with propofol and remifentanil. Anaesthesia was induced so as to maintain BIS values between 40 and 50. Forty-five patients, aged [mean (sd)] 71.1 (5.8) yr, were studied. The mean value of c-fPWV was 12.1 (3.9) m s-1. There was no correlation between hypotension during anaesthesia induction and total dosage or rate of administration of propofol or remifentanil. In univariate analysis, only age and PWV significantly correlated with the decreases in AP, and the association between c-fPWV and a decrease in AP was also seen in multivariate analysis (r=0.36, P-1) had 25 further decrease in systolic AP during anaesthesia induction than those with lower PWV [75.2 (5.7) vs 60.2 (4.2) mm Hg, P

Original languageEnglish
Pages (from-to)583-588
Number of pages6
JournalBritish Journal of Anaesthesia
Issue number5
Publication statusPublished - Nov 2010


  • anaesthesia
  • arterial stiffness
  • elderly
  • hypotension
  • surgery

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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