TY - JOUR
T1 - Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations
AU - Fedirko, Veronika
AU - Romieu, Isabelle
AU - Aleksandrova, Krasimira
AU - Pischon, Tobias
AU - Trichopoulos, Dimitrios
AU - Peeters, Petra H.
AU - Romaguera-Bosch, Dora
AU - Bueno-De-Mesquita, H. B.
AU - Dahm, Christina C.
AU - Overvad, Kim
AU - Chirlaque, Maria Dolores
AU - Johansen, Christoffer
AU - Bidstrup, Pernille E.
AU - Dalton, Susanne O.
AU - Gunter, Marc J.
AU - Wark, Petra A.
AU - Norat, Teresa
AU - Halkjær, Jytte
AU - Tjønneland, Anne
AU - Dik, Vincent K.
AU - Siersema, Peter D.
AU - Boutron-Ruault, Marie Christine
AU - Dossus, Laure
AU - Bastide, Nadia
AU - Kühn, Tilman
AU - Kaaks, Rudolf
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Klinaki, Eleni
AU - Katsoulis, Michalis
AU - Pala, Valeria
AU - Panico, Salvatore
AU - Tumino, Rosario
AU - Palli, Domenico
AU - Vineis, Paolo
AU - Weiderpass, Elisabete
AU - Skeie, Guri
AU - González, Carlos A.
AU - Sánchez, María José
AU - Barricarte, Aurelio
AU - Amiano, Pilar
AU - Quiros, J. Ramon
AU - Manjer, Jonas
AU - Jirström, Karin
AU - Ljuslinder, Ingrid
AU - Palmqvist, Richard
AU - Khaw, Kay Tee
AU - Wareham, Nick
AU - Bradbury, Kathryn E.
AU - Stepien, Magdalena
AU - Duarte-Salles, Talita
AU - Riboli, Elio
AU - Jenab, Mazda
PY - 2014/10/15
Y1 - 2014/10/15
N2 - General and abdominal adiposity are associated with a high risk of developing colorectal cancer (CRC), but the role of these exposures on cancer survival has been less studied. The association between pre-diagnostic anthropometric characteristics and CRC-specific and all-cause death was examined among 3,924 men and women diagnosed with CRC between 1992 and 2009 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). Over a mean follow-up period of 49 months, 1,309 deaths occurred of which 1,043 (79.7%) were due to CRC. In multivariable analysis, pre-diagnostic BMI ≥30 kg/m 2 was associated with a high risk for CRC-specific (HR = 1.26, 95% CI = 1.04-1.52) and all-cause (HR = 1.32, 95% CI = 1.12-1.56) death relative to BMI 2. Every 5 kg/m2 increase in BMI was associated with a high risk for CRC-specific (HR = 1.10, 95% CI = 1.02-1.19) and all-cause death (HR = 1.12, 95% CI = 1.05-1.20); and every 10 cm increase in waist circumference was associated with a high risk for CRC-specific (HR = 1.09, 95% CI = 1.02-1.16) and all-cause death (HR = 1.11, 95% CI = 1.05-1.18). Similar associations were observed for waist-to-hip and waist-to-height ratios. Height was not associated with CRC-specific or all-cause death. Associations tended to be stronger among men than in women. Possible interactions by age at diagnosis, cancer stage, tumour location, and hormone replacement therapy use among postmenopausal women were noted. Pre-diagnostic general and abdominal adiposity are associated with lower survival after CRC diagnosis.
AB - General and abdominal adiposity are associated with a high risk of developing colorectal cancer (CRC), but the role of these exposures on cancer survival has been less studied. The association between pre-diagnostic anthropometric characteristics and CRC-specific and all-cause death was examined among 3,924 men and women diagnosed with CRC between 1992 and 2009 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). Over a mean follow-up period of 49 months, 1,309 deaths occurred of which 1,043 (79.7%) were due to CRC. In multivariable analysis, pre-diagnostic BMI ≥30 kg/m 2 was associated with a high risk for CRC-specific (HR = 1.26, 95% CI = 1.04-1.52) and all-cause (HR = 1.32, 95% CI = 1.12-1.56) death relative to BMI 2. Every 5 kg/m2 increase in BMI was associated with a high risk for CRC-specific (HR = 1.10, 95% CI = 1.02-1.19) and all-cause death (HR = 1.12, 95% CI = 1.05-1.20); and every 10 cm increase in waist circumference was associated with a high risk for CRC-specific (HR = 1.09, 95% CI = 1.02-1.16) and all-cause death (HR = 1.11, 95% CI = 1.05-1.18). Similar associations were observed for waist-to-hip and waist-to-height ratios. Height was not associated with CRC-specific or all-cause death. Associations tended to be stronger among men than in women. Possible interactions by age at diagnosis, cancer stage, tumour location, and hormone replacement therapy use among postmenopausal women were noted. Pre-diagnostic general and abdominal adiposity are associated with lower survival after CRC diagnosis.
KW - abdominal obesity
KW - body composition
KW - colorectal neoplasms
KW - obesity
KW - survival
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U2 - 10.1002/ijc.28841
DO - 10.1002/ijc.28841
M3 - Article
C2 - 24623514
AN - SCOPUS:84905721284
SN - 0020-7136
VL - 135
SP - 1949
EP - 1960
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 8
ER -