Pramipexole in comparison to 1-dopa: A neuropsychological study

L. Brusa, A. Bassi, A. Stefani, M. Pierantozzi, A. Peppe, M. D. Caramia, L. Boffa, S. Ruggieri, P. Stanzione

Research output: Contribution to journalArticlepeer-review


Twenty right-handed patients affected by early/mild Parkinson's disease were evaluated in a randomised study using neuropsychological and clinical assessements during three treatment modalities: when in the off treatment condition, when on pramipexole, and when on 1-dopa. In comparison to the off treatment condition, the DA-agonist pramipexole produced a significant impairment of short term verbal memory, attentional-executive functions and verbal fluency, while 1-dopa did not. Moreover, pramipexole opposite to 1-dopa, failed to improve FAS and Stroop tests. Present findings indicate that pramipexole may worsen cognitive functions although not exceeding normative values.

Original languageEnglish
Pages (from-to)373-380
Number of pages8
JournalJournal of Neural Transmission
Issue number4
Publication statusPublished - Apr 1 2003


  • 1-Dopa
  • Cognitive function
  • DA-agonists

ASJC Scopus subject areas

  • Neuroscience(all)


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