Pramipexole in comparison to 1-dopa: A neuropsychological study

L. Brusa; A. Bassi; A. Stefani; M. Pierantozzi; A. Peppe; M. D. Caramia; L. Boffa; S. Ruggieri; P. Stanzione

doi:10.1007/s00702-002-0811-7

Pramipexole in comparison to 1-dopa: A neuropsychological study

L. Brusa, A. Bassi, A. Stefani, M. Pierantozzi, A. Peppe, M. D. Caramia, L. Boffa, S. Ruggieri, P. Stanzione

Research output: Contribution to journal › Article › peer-review

Abstract

Twenty right-handed patients affected by early/mild Parkinson's disease were evaluated in a randomised study using neuropsychological and clinical assessements during three treatment modalities: when in the off treatment condition, when on pramipexole, and when on 1-dopa. In comparison to the off treatment condition, the DA-agonist pramipexole produced a significant impairment of short term verbal memory, attentional-executive functions and verbal fluency, while 1-dopa did not. Moreover, pramipexole opposite to 1-dopa, failed to improve FAS and Stroop tests. Present findings indicate that pramipexole may worsen cognitive functions although not exceeding normative values.

Original language	English
Pages (from-to)	373-380
Number of pages	8
Journal	Journal of Neural Transmission
Volume	110
Issue number	4
DOIs	https://doi.org/10.1007/s00702-002-0811-7
Publication status	Published - Apr 1 2003

Keywords

1-Dopa
Cognitive function
DA-agonists

ASJC Scopus subject areas

Neuroscience(all)

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10.1007/s00702-002-0811-7

Cite this

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abstract = "Twenty right-handed patients affected by early/mild Parkinson's disease were evaluated in a randomised study using neuropsychological and clinical assessements during three treatment modalities: when in the off treatment condition, when on pramipexole, and when on 1-dopa. In comparison to the off treatment condition, the DA-agonist pramipexole produced a significant impairment of short term verbal memory, attentional-executive functions and verbal fluency, while 1-dopa did not. Moreover, pramipexole opposite to 1-dopa, failed to improve FAS and Stroop tests. Present findings indicate that pramipexole may worsen cognitive functions although not exceeding normative values.",

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AU - Pierantozzi, M.

AU - Peppe, A.

AU - Caramia, M. D.

AU - Boffa, L.

AU - Ruggieri, S.

AU - Stanzione, P.

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Pramipexole in comparison to 1-dopa: A neuropsychological study

Abstract

Keywords

ASJC Scopus subject areas

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