Potentiation of the baroreceptor-heart rate reflex by sympathectomy in conscious rats

A. U. Ferrari, A. Daffonchio, C. Franzelli, G. Mancia

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In both animals and humans, stimuli leading to sympathetic activation are accompanied by an impairment of the baroreceptor-heart rate reflex. To determine whether sympathetic activity normally interferes with this reflex function we examined in conscious Wistar-Kyoto (WKY) rats the effect of chemical sympathectomy by 6-hydroxydopamine on the bradycardic response to baroreceptor stimulation induced by raising blood pressure via intravenous phenylephrine boluses; control rats received vehicle. Spontaneously hypertensive rats were also studied because in these animals there is both a baroreceptor reflex impairment and a sympathetic overactivity. Baroreceptor reflex sensitivity, calculated as the ratio of the peak increase in pulse interval to the peak increase in mean arterial pressure, was 75% greater in sympathectomized WKY rats than in control WKY rats (1.28±0.15 versus 0.73±0.10 msec/mm Hg, mean±SEM; p

Original languageEnglish
Pages (from-to)230-235
Number of pages6
Issue number2
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Internal Medicine


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