TY - JOUR
T1 - Potential role of type i interferons in the treatment of pituitary adenomas
AU - Vitale, Giovanni
AU - Caraglia, Michele
AU - Van Koetsveld, Peter M.
AU - Maroni, Paola
AU - Marra, Monica
AU - Colao, Annamaria
AU - Lamberts, Steven W J
AU - Cavagnini, Francesco
AU - Hofland, Leo J.
PY - 2009/6
Y1 - 2009/6
N2 - Cytokines, particularly those endowed with pro-inflammatory properties, are known to influence the release of anterior pituitary hormones by a direct and indirect action at the level of pituitary gland and hypothalamus. Type I interferons (IFNs) represent a group of cytokines that act through a common receptor composed by two chains (IFNAR-1 and IFNAR-2). Several in vitro and in vivo studies underline the fact that type I IFNs are involved in the regulation of the immune-endocrine circuitry. Treatment with type I IFNs of patients affected by chronic viral hepatitis, multiple sclerosis and tumors influences the secretion of pituitary hormones. This article reviews the current knowledge about the effects of IFN-α and IFN-β on hypothalamic-pituitary function and describes the potential role of type I IFNs in the treatment of pituitary adenomas.
AB - Cytokines, particularly those endowed with pro-inflammatory properties, are known to influence the release of anterior pituitary hormones by a direct and indirect action at the level of pituitary gland and hypothalamus. Type I interferons (IFNs) represent a group of cytokines that act through a common receptor composed by two chains (IFNAR-1 and IFNAR-2). Several in vitro and in vivo studies underline the fact that type I IFNs are involved in the regulation of the immune-endocrine circuitry. Treatment with type I IFNs of patients affected by chronic viral hepatitis, multiple sclerosis and tumors influences the secretion of pituitary hormones. This article reviews the current knowledge about the effects of IFN-α and IFN-β on hypothalamic-pituitary function and describes the potential role of type I IFNs in the treatment of pituitary adenomas.
KW - ACTH
KW - GH
KW - Hypothalamic-pituitary function
KW - Pituitary adenomas
KW - Type I interferons
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U2 - 10.1007/s11154-008-9083-3
DO - 10.1007/s11154-008-9083-3
M3 - Article
C2 - 18604644
AN - SCOPUS:67349247100
SN - 1389-9155
VL - 10
SP - 125
EP - 133
JO - Reviews in Endocrine and Metabolic Disorders
JF - Reviews in Endocrine and Metabolic Disorders
IS - 2
ER -