Posterior reversible encephalopathy syndrome in intensive care medicine

Giuseppe Servillo, Francesca Bifulco, Edoardo De Robertis, Ornella Piazza, Pasquale Striano, Fabio Tortora, Salvatore Striano, Rosalba Tufano

Research output: Contribution to journalArticlepeer-review


Background: Posterior reversible encephalopathy syndrome (PRES) is a well-recognized clinico-neuroradiological transient condition. Early recognition is of paramount importance for prompt control of blood pressure or removal of precipitating factors and treatment of epileptic seizures or status epilepticus. Delay in the diagnosis and treatment may in fact results in death or in irreversible neurological sequelae. Discussion: PRES is characterized by headache, altered mental status, seizures, and visual disturbances and is associated with a number of different causes, most commonly acute hypertension, preeclampsia/eclampsia, and immunosuppressive agents. Clinical symptoms and neuroradiological findings are typically indistinguishable among the cases of PRES, regardless of underlying cause. Magnetic resonance studies typically show edema involving the white matter of cerebral posterior regions, especially parieto-occipital lobes but frontal and temporal lobes, and other encephalic structures may be involved. Conclusions: Intensivists and other physicians involved in the evaluation of patients with presumed PRES must be aware of the clinical spectrum of the associated conditions, the diagnostic modalities, and the correct treatment.

Original languageEnglish
Pages (from-to)230-236
Number of pages7
JournalIntensive Care Medicine
Issue number2
Publication statusPublished - Feb 2007


  • Eclampsia
  • Encephalopathy
  • Intensive care
  • Magnetic resonance imaging
  • Posterior reversible encephalopathy syndrome

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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