Postbiotics — when simplification fails to clarify

José Eleazar Aguilar-Toalá; Stefania Arioli; Pradip Behare; Clara Belzer; Roberto Berni Canani; Jean Marc Chatel; Enza D’Auria; Mônica Queiroz de Freitas; Eran Elinav; Erick Almeida Esmerino; Hugo S. García; Adriano Gomes da Cruz; Aarón F. González-Córdova; Simone Guglielmetti; Jonas de Toledo Guimarães; Adrián Hernández-Mendoza; Philippe Langella; Andrea M. Liceaga; Marciane Magnani; Rebeca Martin; Mohammad Tamrin Mohamad Lal; Diego Mora; Mehran Moradi; Lorenzo Morelli; Fabio Mosca; Filomena Nazzaro; Tatiana Colombo Pimentel; Chao Ran; Chaminda Senaka Ranadheera; Maria Rescigno; Azucena Salas; Anderson S. Sant’Ana; Katia Sivieri; Harry Sokol; Valentina Taverniti; Belinda Vallejo-Cordoba; Jaroslav Zelenka; Zhigang Zhou

doi:10.1038/s41575-021-00521-6

Postbiotics — when simplification fails to clarify

José Eleazar Aguilar-Toalá, Stefania Arioli, Pradip Behare, Clara Belzer, Roberto Berni Canani, Jean Marc Chatel, Enza D’Auria, Mônica Queiroz de Freitas, Eran Elinav, Erick Almeida Esmerino, Hugo S. García, Adriano Gomes da Cruz, Aarón F. González-Córdova, Simone Guglielmetti, Jonas de Toledo Guimarães, Adrián Hernández-Mendoza, Philippe Langella, Andrea M. Liceaga, Marciane Magnani, Rebeca MartinMohammad Tamrin Mohamad Lal, Diego Mora, Mehran Moradi, Lorenzo Morelli, Fabio Mosca, Filomena Nazzaro, Tatiana Colombo Pimentel, Chao Ran, Chaminda Senaka Ranadheera, Maria Rescigno, Azucena Salas, Anderson S. Sant’Ana, Katia Sivieri, Harry Sokol, Valentina Taverniti, Belinda Vallejo-Cordoba, Jaroslav Zelenka, Zhigang Zhou

Research output: Contribution to journal › Letter › peer-review

Original language	English
Pages (from-to)	825-826
Journal	Nature Reviews Gastroenterology and Hepatology
Volume	18
Issue number	11
DOIs	https://doi.org/10.1038/s41575-021-00521-6
Publication status	Published - 2021

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1038/s41575-021-00521-6

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Aguilar-Toalá, J. E., Arioli, S., Behare, P., Belzer, C., Berni Canani, R., Chatel, J. M., D’Auria, E., de Freitas, M. Q., Elinav, E., Esmerino, E. A., García, H. S., da Cruz, A. G., González-Córdova, A. F., Guglielmetti, S., de Toledo Guimarães, J., Hernández-Mendoza, A., Langella, P., Liceaga, A. M., Magnani, M., ... Zhou, Z. (2021). Postbiotics — when simplification fails to clarify. Nature Reviews Gastroenterology and Hepatology, 18(11), 825-826. https://doi.org/10.1038/s41575-021-00521-6

Aguilar-Toalá, JE, Arioli, S, Behare, P, Belzer, C, Berni Canani, R, Chatel, JM, D’Auria, E, de Freitas, MQ, Elinav, E, Esmerino, EA, García, HS, da Cruz, AG, González-Córdova, AF, Guglielmetti, S, de Toledo Guimarães, J, Hernández-Mendoza, A, Langella, P, Liceaga, AM, Magnani, M, Martin, R, Mohamad Lal, MT, Mora, D, Moradi, M, Morelli, L, Mosca, F, Nazzaro, F, Pimentel, TC, Ran, C, Ranadheera, CS, Rescigno, M, Salas, A, Sant’Ana, AS, Sivieri, K, Sokol, H, Taverniti, V, Vallejo-Cordoba, B, Zelenka, J & Zhou, Z 2021, 'Postbiotics — when simplification fails to clarify', Nature Reviews Gastroenterology and Hepatology, vol. 18, no. 11, pp. 825-826. https://doi.org/10.1038/s41575-021-00521-6

@article{4d1134ae61604243812c3ad96269ac2a,

title = "Postbiotics — when simplification fails to clarify",

author = "Aguilar-Toal{\'a}, {Jos{\'e} Eleazar} and Stefania Arioli and Pradip Behare and Clara Belzer and {Berni Canani}, Roberto and Chatel, {Jean Marc} and Enza D{\textquoteright}Auria and {de Freitas}, {M{\^o}nica Queiroz} and Eran Elinav and Esmerino, {Erick Almeida} and Garc{\'i}a, {Hugo S.} and {da Cruz}, {Adriano Gomes} and Gonz{\'a}lez-C{\'o}rdova, {Aar{\'o}n F.} and Simone Guglielmetti and {de Toledo Guimar{\~a}es}, Jonas and Adri{\'a}n Hern{\'a}ndez-Mendoza and Philippe Langella and Liceaga, {Andrea M.} and Marciane Magnani and Rebeca Martin and {Mohamad Lal}, {Mohammad Tamrin} and Diego Mora and Mehran Moradi and Lorenzo Morelli and Fabio Mosca and Filomena Nazzaro and Pimentel, {Tatiana Colombo} and Chao Ran and Ranadheera, {Chaminda Senaka} and Maria Rescigno and Azucena Salas and Sant{\textquoteright}Ana, {Anderson S.} and Katia Sivieri and Harry Sokol and Valentina Taverniti and Belinda Vallejo-Cordoba and Jaroslav Zelenka and Zhigang Zhou",

note = "Funding Information: S.A. has research projects sponsored by Sofar, Sacco, Sanofi and Actial Farmaceutica. P.B. has been receiving grants from Ministry of Food Processing Industries for health-promoting exopolysaccharides derived from lactic and probiotic bacteria. C.B. has led research projects sponsored by several industry partners such as Danone-Nutrica, FreislandCampina and Sensus. R.B.C. had the following relevant financial relationships with the following manufacturers: Ch.Hansen (research grant, speaker), iHealth (research grant), Humana (research grant), Kraft-Heinz (research grant, speaker), Mead Johnson Nutrition (research grant, speaker), Nestl{\`e} (research grant, speaker), Novalac (research grant), Nutricia (research grant, speaker) and Sofar (research grant) as part of publically funded research projects with the support of the Italian Ministry of Health. E.E. is the founding scientist of DayTwo and BiomX. None of the activities of these entities is related to the topics presented in this commentary. S.G. has led research projects sponsored by several industry partners such as Sofar, 7 Inv, Sacco, Metis Healthcare, Giellepi and Perfetti-Van Melle. S.G. is a consultant for Sofar and Perfetti Van Melle. S.G. receives royalties from the sale of probiotic bacterial strains. P.L. has led research projects with several agro-food (Danone, General Mills, Dupond and Lallemand), food supplements (Pil{\`e}je), biotech (Ysopia) and pharmaceutical (Biocodex and Merck) companies and is a co-founder of Exeliom bioscience. M. Magnani has participated in research projects sponsored by industrial partners such as Farmoqu{\'i}mica and Danone Nutricia, the latter not for study of probiotics. D.M. is in the Scientific Advisory Board of Actial Farmaceutica. L.M. is consultant at Bayer, Ferrero, Sanofi and DSM and shareholder in Advanced Analytical Technologies. F.N. participated in a research project funded by Eurolactis (Luxemburg). M.R. has received funding for research collaborations by Kraft-Heinz; Gelesis; and AlfaSigma. She is in the advisory board of MillBo and Gelesis. She is founder and CSO of Postbiotica. K.S. has projects sponsored by industrial partners such as Nestl{\'e} and Danone Nutricia, the latter not for the study of probiotics or prebiotics. H.S. received unrestricted study grants from Danone, Biocodex and Enterome; board membership, consultancy, or lecture fees from Carenity, Abbvie, Astellas, Danone, Ferring, Mayoly Spindler, M.S.D., Novartis, Roche, Tillots, Enterome, Maat, BiomX, Biose, Novartis and Takeda; and is a co-founder of Exeliom bioscience. V.T. receives royalties from the sale of viable and inactivated probiotic bacterial strains. M. Moradi declares that he has no task or primary function other than the research and education in his university/country. The other authors declare no competing interests.",

year = "2021",

doi = "10.1038/s41575-021-00521-6",

language = "English",

volume = "18",

pages = "825--826",

journal = "Nature Reviews Gastroenterology and Hepatology",

issn = "1759-5045",

publisher = "Nature Publishing Group",

number = "11",

}

TY - JOUR

T1 - Postbiotics — when simplification fails to clarify

AU - Aguilar-Toalá, José Eleazar

AU - Arioli, Stefania

AU - Behare, Pradip

AU - Belzer, Clara

AU - Berni Canani, Roberto

AU - Chatel, Jean Marc

AU - D’Auria, Enza

AU - de Freitas, Mônica Queiroz

AU - Elinav, Eran

AU - Esmerino, Erick Almeida

AU - García, Hugo S.

AU - da Cruz, Adriano Gomes

AU - González-Córdova, Aarón F.

AU - Guglielmetti, Simone

AU - de Toledo Guimarães, Jonas

AU - Hernández-Mendoza, Adrián

AU - Langella, Philippe

AU - Liceaga, Andrea M.

AU - Magnani, Marciane

AU - Martin, Rebeca

AU - Mohamad Lal, Mohammad Tamrin

AU - Mora, Diego

AU - Moradi, Mehran

AU - Morelli, Lorenzo

AU - Mosca, Fabio

AU - Nazzaro, Filomena

AU - Pimentel, Tatiana Colombo

AU - Ran, Chao

AU - Ranadheera, Chaminda Senaka

AU - Rescigno, Maria

AU - Salas, Azucena

AU - Sant’Ana, Anderson S.

AU - Sivieri, Katia

AU - Sokol, Harry

AU - Taverniti, Valentina

AU - Vallejo-Cordoba, Belinda

AU - Zelenka, Jaroslav

AU - Zhou, Zhigang

N1 - Funding Information: S.A. has research projects sponsored by Sofar, Sacco, Sanofi and Actial Farmaceutica. P.B. has been receiving grants from Ministry of Food Processing Industries for health-promoting exopolysaccharides derived from lactic and probiotic bacteria. C.B. has led research projects sponsored by several industry partners such as Danone-Nutrica, FreislandCampina and Sensus. R.B.C. had the following relevant financial relationships with the following manufacturers: Ch.Hansen (research grant, speaker), iHealth (research grant), Humana (research grant), Kraft-Heinz (research grant, speaker), Mead Johnson Nutrition (research grant, speaker), Nestlè (research grant, speaker), Novalac (research grant), Nutricia (research grant, speaker) and Sofar (research grant) as part of publically funded research projects with the support of the Italian Ministry of Health. E.E. is the founding scientist of DayTwo and BiomX. None of the activities of these entities is related to the topics presented in this commentary. S.G. has led research projects sponsored by several industry partners such as Sofar, 7 Inv, Sacco, Metis Healthcare, Giellepi and Perfetti-Van Melle. S.G. is a consultant for Sofar and Perfetti Van Melle. S.G. receives royalties from the sale of probiotic bacterial strains. P.L. has led research projects with several agro-food (Danone, General Mills, Dupond and Lallemand), food supplements (Pilèje), biotech (Ysopia) and pharmaceutical (Biocodex and Merck) companies and is a co-founder of Exeliom bioscience. M. Magnani has participated in research projects sponsored by industrial partners such as Farmoquímica and Danone Nutricia, the latter not for study of probiotics. D.M. is in the Scientific Advisory Board of Actial Farmaceutica. L.M. is consultant at Bayer, Ferrero, Sanofi and DSM and shareholder in Advanced Analytical Technologies. F.N. participated in a research project funded by Eurolactis (Luxemburg). M.R. has received funding for research collaborations by Kraft-Heinz; Gelesis; and AlfaSigma. She is in the advisory board of MillBo and Gelesis. She is founder and CSO of Postbiotica. K.S. has projects sponsored by industrial partners such as Nestlé and Danone Nutricia, the latter not for the study of probiotics or prebiotics. H.S. received unrestricted study grants from Danone, Biocodex and Enterome; board membership, consultancy, or lecture fees from Carenity, Abbvie, Astellas, Danone, Ferring, Mayoly Spindler, M.S.D., Novartis, Roche, Tillots, Enterome, Maat, BiomX, Biose, Novartis and Takeda; and is a co-founder of Exeliom bioscience. V.T. receives royalties from the sale of viable and inactivated probiotic bacterial strains. M. Moradi declares that he has no task or primary function other than the research and education in his university/country. The other authors declare no competing interests.

PY - 2021

Y1 - 2021

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AN - SCOPUS:85115417794

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VL - 18

SP - 825

EP - 826

JO - Nature Reviews Gastroenterology and Hepatology

JF - Nature Reviews Gastroenterology and Hepatology

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ER -

Postbiotics — when simplification fails to clarify

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